Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.

Balzarini, J; Degrève, B; Andrei, G; Neyts, J; Sandvold, M; Myhren, F; de Clercq, E

Balzarini, J; Degrève, B; Andrei, G; Neyts, J; Sandvold, M; Myhren, F; de Clercq, E.

Affiliation

Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

Gene Ther ; 5(3): 419-26, 1998 Mar.

Article in En | MEDLINE | ID: mdl-9614564

Subject(s)

Antiviral Agents/pharmacology; Ganciclovir/analogs & derivatives; Herpesvirus 1, Human/drug effects; Mammary Neoplasms, Experimental/metabolism; Prodrugs/pharmacology; Animals; Antiviral Agents/metabolism; Cell Division/drug effects; Female; Ganciclovir/metabolism; Ganciclovir/pharmacology; Genetic Therapy; Half-Life; Herpesvirus 1, Human/physiology; Humans; Mammary Neoplasms, Experimental/pathology; Mice; Prodrugs/metabolism; Thymidine Kinase/genetics; Transfection; Tumor Cells, Cultured; Virus Replication/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Prodrugs / Ganciclovir / Herpesvirus 1, Human / Mammary Neoplasms, Experimental Limits: Animals / Female / Humans Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 1998 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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