Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands.

Huang, Y; Hammond, P S; Whirrett, B R; Kuhner, R J; Wu, L; Childers, S R; Mach, R H

Huang, Y; Hammond, P S; Whirrett, B R; Kuhner, R J; Wu, L; Childers, S R; Mach, R H.

Affiliation

Huang Y; Department of Radiology-PET Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

J Med Chem ; 41(13): 2361-70, 1998 Jun 18.

Article in En | MEDLINE | ID: mdl-9632369

Subject(s)

Acetamides; Acetanilides; Benzamides; Piperidines; Receptors, sigma/metabolism; Acetamides/chemical synthesis; Acetamides/chemistry; Acetamides/metabolism; Animals; Benzamides/chemical synthesis; Benzamides/chemistry; Benzamides/metabolism; Brain/metabolism; Guinea Pigs; Ligands; Liver/metabolism; Male; Piperidines/chemical synthesis; Piperidines/chemistry; Piperidines/metabolism; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Benzamides / Receptors, sigma / Acetamides / Acetanilides Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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