Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors.

Giuliano, M; Lauricella, M; Vassallo, E; Carabillò, M; Vento, R; Tesoriere, G

Giuliano, M; Lauricella, M; Vassallo, E; Carabillò, M; Vento, R; Tesoriere, G.

Affiliation

Giuliano M; Institute of Biological Chemistry, University of Palermo, Italy.

Invest Ophthalmol Vis Sci ; 39(8): 1300-11, 1998 Jul.

Article in En | MEDLINE | ID: mdl-9660477

Subject(s)

Apoptosis/drug effects; DNA, Neoplasm/drug effects; Enzyme Inhibitors/pharmacology; Retinal Neoplasms/pathology; Retinoblastoma/pathology; Topoisomerase I Inhibitors; Amsacrine/pharmacology; Camptothecin/pharmacology; Cell Survival/drug effects; Cyclin-Dependent Kinase Inhibitor p21; Cyclins/metabolism; Cycloheximide/pharmacology; DNA Damage/drug effects; DNA Topoisomerases, Type I/metabolism; DNA, Neoplasm/analysis; Dactinomycin/pharmacology; Etoposide/pharmacology; Humans; Insulin-Like Growth Factor Binding Protein 3/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Retinal Neoplasms/drug therapy; Retinal Neoplasms/enzymology; Retinoblastoma/drug therapy; Retinoblastoma/enzymology; Tumor Cells, Cultured; Tumor Suppressor Protein p53/metabolism; bcl-2-Associated X Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Retinoblastoma / DNA, Neoplasm / Apoptosis / Retinal Neoplasms / Enzyme Inhibitors / Topoisomerase I Inhibitors Limits: Humans Language: En Journal: Invest Ophthalmol Vis Sci Year: 1998 Document type: Article Affiliation country: Italy

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