A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.

Parasol, N; Reid, M; Rios, M; Castilho, L; Harari, I; Kosower, N S

Parasol, N; Reid, M; Rios, M; Castilho, L; Harari, I; Kosower, N S.

Affiliation

Parasol N; Department of Human Genetics, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Blood ; 92(7): 2237-43, 1998 Oct 01.

Article in En | MEDLINE | ID: mdl-9746760

Subject(s)

Alleles; Antigens, Protozoan; Black People/genetics; Carrier Proteins/genetics; Duffy Blood-Group System/genetics; Erythrocyte Membrane/chemistry; Jews/genetics; Point Mutation; Protozoan Proteins; Receptors, Cell Surface/genetics; Agglutination Tests; Animals; Binding Sites; Brazil; Carrier Proteins/biosynthesis; DNA Mutational Analysis; DNA-Binding Proteins/metabolism; Disease Susceptibility; Erythrocyte Membrane/metabolism; Erythrocyte Membrane/ultrastructure; Erythroid-Specific DNA-Binding Factors; Gene Expression Regulation; Gene Frequency; Humans; Malaria, Vivax/ethnology; Malaria, Vivax/genetics; Phenotype; Plasmodium vivax/metabolism; Polymorphism, Restriction Fragment Length; Receptors, Cell Surface/biosynthesis; Transcription Factors/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Jews / Carrier Proteins / Protozoan Proteins / Point Mutation / Receptors, Cell Surface / Black People / Duffy Blood-Group System / Alleles / Erythrocyte Membrane / Antigens, Protozoan Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Blood Year: 1998 Document type: Article Affiliation country: Israel Country of publication: United States

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