Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1.

Kvassman, J O; Verhamme, I; Shore, J D

Kvassman, J O; Verhamme, I; Shore, J D.

Affiliation

Kvassman JO; Henry Ford Health Sciences Center, Division of Biochemical Research, Detroit, Michigan, USA. jkvassm1@hfhs.org

Biochemistry ; 37(44): 15491-502, 1998 Nov 03.

Article in En | MEDLINE | ID: mdl-9799512

Subject(s)

Plasminogen Activator Inhibitor 1/chemistry; Plasminogen Activator Inhibitor 1/metabolism; Plasminogen Activators/antagonists & inhibitors; Plasminogen Activators/metabolism; Protein Structure, Secondary; Acylation; Animals; Binding Sites; Catalysis; Cattle; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Plasminogen Activator Inhibitor 1/pharmacology; Plasminogen Activators/chemistry; Serine/metabolism; Substrate Specificity; Tissue Plasminogen Activator/metabolism; Trypsin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen Activators / Protein Structure, Secondary / Plasminogen Activator Inhibitor 1 Limits: Animals / Humans Language: En Journal: Biochemistry Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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