Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations.

Irie, F; Hirabayashi, Y

Irie, F; Hirabayashi, Y.

Affiliation

Irie F; Laboratory for Cellular Glycobiology, Frontier Research Program, The Institute Physical and Chemical Research (RIKEN), Wako, Saitama, Japan. irie@postman.riken.go.jp

J Neurosci Res ; 54(4): 475-85, 1998 Nov 15.

Article in En | MEDLINE | ID: mdl-9822158

Subject(s)

Apoptosis/drug effects; Ceramides/pharmacology; Motor Neurons/drug effects; 1-Deoxynojirimycin/analogs & derivatives; 1-Deoxynojirimycin/pharmacology; Animals; Axons/drug effects; Axons/physiology; Cell Nucleus/drug effects; Cell Size/drug effects; Cell Survival/drug effects; Cells, Cultured; Ceramides/metabolism; Chromatin/metabolism; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Glucosylceramides/metabolism; Motor Neurons/chemistry; Motor Neurons/cytology; Motor Neurons/metabolism; Rats; Sphingolipids/analysis; Sphingomyelin Phosphodiesterase/metabolism; Spinal Cord/cytology; Stereoisomerism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Ceramides / Apoptosis / Motor Neurons Limits: Animals Language: En Journal: J Neurosci Res Year: 1998 Document type: Article Affiliation country: Japan Country of publication: United States

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