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Murine gamma-herpesvirus 68 glycoprotein 150 protects against virus-induced mononucleosis: a model system for gamma-herpesvirus vaccination.
Stewart, J P; Micali, N; Usherwood, E J; Bonina, L; Nash, A A.
Affiliation
  • Stewart JP; Department of Veterinary Pathology, University of Edinburgh, UK. james.stewart@ed.ac.uk
Vaccine ; 17(2): 152-7, 1999 Jan.
Article in En | MEDLINE | ID: mdl-9987149
Murine gamma-herpesvirus 68 (MHV-68) is a model for the study of the pathogenesis of gamma-herpesviruses. Epstein-Barr virus (EBV) is a highly related gamma-herpesvirus that causes significant disease in humans. The major membrane antigen gp350 of EBV is a candidate vaccine antigen for protection against EBV-related disease. An MHV-68 glycoprotein, gp150, has significant homology to EBV gp350. We have therefore used the MHV-68 gp150 to model the potential efficacy of EBV gp350 in protecting from virus-associated disease. A recombinant vaccinia virus expressing MHV-68 gp150 was constructed. This recombinant vaccinia virus was used to infect mice via the subcutaneous route. This vaccination resulted in production of MHV-68-neutralising antibodies. Mice were then challenged intra-nasally with MHV-68. MHV-68-associated mononucleosis was virtually abrogated in immunised mice. However, mice did establish MHV-68 latency. The results suggest that gp350 may be effective as an immunogen to prevent EBV-associated infectious mononucleosis in humans that are EBV-seronegative.
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Collection: 01-internacional Database: MEDLINE Main subject: Viral Vaccines / Gammaherpesvirinae / Herpesviridae Infections / Infectious Mononucleosis Limits: Animals / Female / Humans Language: En Journal: Vaccine Year: 1999 Document type: Article Country of publication: Netherlands
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Collection: 01-internacional Database: MEDLINE Main subject: Viral Vaccines / Gammaherpesvirinae / Herpesviridae Infections / Infectious Mononucleosis Limits: Animals / Female / Humans Language: En Journal: Vaccine Year: 1999 Document type: Article Country of publication: Netherlands