Efficacy and safety of medium term indapamide treatment in hypertensive diabetic patients

ABSTRACT

To assess the efficacy and safety of Indapamide, 33 maturity onset diabetics with essential hypertension were treated with Indapamide for 90 days at the single daily dose of 2.5 mg. These patients responded well to treatment as early as the tenth day, the diastolic blood pressure decreased by 10 mm Hg (p<0.01). At the second month, blood pressure on average was normalized. At the third month, the blood pressure decrease was 16 mm Hg for diastolic and 25.5 mm Hg for systolic. The two-hour post-breakfast blood sugar level was not significantly modified, nor were the other biological parameters monitored serum creatinine, serum uric acid and serum potassium levels. Indapamide at 2.5 mg per day is effective and safe in hypertensive diabetic patients (AU)