Coagulation changes during the steady state in homozygous sickle-cell disease in Jamaica
Br J Haematol
; 30(2): 159-66, June 1975.
Article
in En
| MedCarib
| ID: med-12994
Responsible library:
JM3.1
Localization: JM3.1; RB145.A1B7
ABSTRACT
Coagulation studies were carried out in 117 Jamaicans with homozygous sickle-cell disease in the steady state, and 40 local controls. The patients had significantly higher factor-VIII levels, higher platelet counts, lower factor-V and plasminogen levels, shorter thrombin times and higher serum fibrinogen degradation products(FDP) than the control group. The low factor-V and plasminogen levels, and high FDP levels, might be explained by activation of the coagulation system and continuous clot lysis even in the absence of painful crisis. The high factor-VIII levels and short thrombin times found in these patients could not be explained.(Summary)
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Collection:
01-internacional
Database:
MedCarib
Main subject:
Blood Coagulation
/
Anemia, Sickle Cell
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Caribe ingles
/
Jamaica
Language:
En
Journal:
Br J Haematol
Year:
1975
Document type:
Article