A revision of trypanosoma (schizotrypanum) cruzi strains from British Honduras, and the importance of strain characteristics in experimental chemotherapy of Chagas' disease
Trans R Soc Trop Med Hyg
; 66(3): 463-70, 1972.
Article
in English
| MedCarib
| ID: med-14767
Responsible library:
JM3.1
Localization: JM3.1; RC960.R6
ABSTRACT
The characteristics of 10 strains of Trypanosoma cruzi from British Honduras are reviewed and discussed. The strains were isolated from the faeces of wild-caught Triatoma dimidiata and all proved to be highly pathogenic to white mice and rats and to certain species of wild rodents. All the strains were characterized by a high cardiotropism, which did not diminish even after prolonged passage in further animals. A variable degree of neurotropism, characterized by parlysis of the limbs, produced by the strains was observed in many laboratory animal as well as in some of the experimentally infected wild rodents. Histological studies of organs from several of the paralized animals failed to provide definitive clues as to the origin of the paralysis. A wide range of dimorphism was observed in the blood-forms of T. cruzi from each of the isolated strains; this dimorphism and the mean nuclear index number changed during each passage. The morphogenisis of the parasites in tissues, in the insect vector, and in NNN culture medium, was found to include amastigote, sphaeromastigote, epimastigote and transitional trypomastigote forms, all leading to the formation of the infective trypanosome form. The importance of co-ordinated studies on the biological and physiological characteristics of T. cruzi strains from man, animal reservoirs, and triatomine insect vectors, from the regions where Chagas' disease is endemic, is emphasized as one of the fundamental requirements for the experimental chemotherapy of Chagas' disease (AU)
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Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Chagas Disease
/
Neglected Diseases
Database:
MedCarib
Main subject:
Trypanosoma cruzi
/
Chagas Disease
Type of study:
Etiology study
Limits:
Animals
/
Humans
Country/Region as subject:
Central America
/
Belize
/
English Caribbean
/
Honduras
Language:
English
Journal:
Trans R Soc Trop Med Hyg
Year:
1972
Document type:
Article