Parasitological and clinical responses of lambs experimentally infected with Haemonchus contortus (L3) with and without ivermectin treatment
Veterinary parasitology
; 166(1-2): 119-123, Dec. 2009. tab, graf
Article
in English
| MedCarib
| ID: med-17638
Responsible library:
TT5
Localization: TT5; W1, VE933U
ABSTRACT
Haemonchus contortus is one of the most important parasites that infects sheep and exerts its pathogenic effects by sucking blood, causing disturbances of organ-functions and thus inducing alterations in various normal physiological parameters. Changes in live body weight, faecal egg count, kinetics of circulating eosinophils and PCV value were studied at weekly interval for a period of 84 days in 18 lambs of local breed after infection with a single dose of 5000 H. contortus (L(3)). In the two groups of lambs infected with nematodes both non-treated and treated with ivermectin (HcNT and HcIT), similar egg excretion patterns was observed starting from third week after infection, with a regular increase in FEC. Examination of whole abomasum of each animal revealed no developmental stage of nematode from treated and control lambs on day 84. The total mean number of H. contortus worms recovered at necropsy from abomasa of untreated infected lambs (group HcNT) was 2576.2 (+/-221.0). The significant loss of body weight, development of heavy worm burden and severe anaemia as indicated by reduced PCV in untreated infected lambs indicated high susceptibility of the lambs to H. contortus. On the other hand, complete absence of the parasite, improved PCV value and body weight after treatment of infected animals (HcIT) proved 100% efficacy of ivermectin against H. contortus.
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Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
MedCarib
Main subject:
Sheep Diseases
/
Sheep
/
Eosinophils
/
Haemonchus
/
Anemia
Limits:
Animals
Language:
English
Journal:
Veterinary parasitology
Year:
2009
Document type:
Article
Institution/Affiliation country:
Addis Ababa University/Ethiopia
/
Haramaya University/Ethiopia
/
The University of the West Indies/Trinidad and Tobago