Investigation of the wound healing activity of Carapa guianensis L. (Meliaceae) bark extract in rats using excision, incision, and dead space wound models
Journal of medicinal food
; 13(5): 1141-1146, Oct. 2010.
Article
in English
| MedCarib
| ID: med-17675
Responsible library:
TT5
ABSTRACT
The objective of our study is to investigate the wound healing activity of the bark extract of Carapa guianensis in rats using three different wound models. The animals were randomly divided into two groups of six each in all the models. Test group animals were treated topically with the bark extract (200 mg/kg of body weight), and the controls were treated with petroleum jelly in the excision wound model. In the incision and dead space wound models the test group animals were treated with the extract of C. guianensis (200 mg/kg/day) orally by mixing in drinking water, and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, period of epithelialization, skin breaking strength, granulation tissue weight, and hydoxyproline content. Antimicrobial activities of the extract against the microorganisms were also assessed. On day 15 extract-treated animals exhibited 99% reduction in the wound area compared to controls (93%). The extract-treated wounds were found to epithelialize faster than controls (P < .02). The skin breaking strength was significantly higher in extract-treated animals compared to controls (P < .001). The weight and hydroxyproline content of granulation tissue were significantly increased compared to controls. These observations support the use of C. guianensis is in the management of wound healing.
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Collection:
International databases
Database:
MedCarib
Main subject:
Rats
/
Trinidad and Tobago
/
Wound Healing
/
Meliaceae
/
Hydroxyproline
Limits:
Animals
Country/Region as subject:
English Caribbean
/
Trinidad and Tobago
Language:
English
Journal:
Journal of medicinal food
Year:
2010
Document type:
Article
Institution/Affiliation country:
North Central Regional Health Authority/Trinidad and Tobago
/
The University of the West Indies/Trinidad and Tobago