Een onderzoek naar de aanwezigheid van amodiaquine in de urine na orale toediening / A research into the presence of amodiaquine in the urine after oral administration

ABSTRACT

Amodiaquine (Camoquin R) is an antimalarial, that belongs to the group of 4-aminoquinoline-derivates. Since 1968 it is being used in the Surinamese battle against malaria. In the Surinamese interior, ADQ (Amodiaquine) is administered as an additive to kitchen-salt, in a concentration of 0,4 per cent (WHO/Mem/l, 1960). To obtain an impression of the presence of ADQ in the urine, an attempt has been made to put up a laboratory determination. The relation between the presence of ADQ in consumed salt, and the occurrence in urine, had to be determined up to a concentration of 1/10000 M. Some inhabitants of the area around the Upper-Suriname river were examined, but ADQ was found in none of them. These negative results are probably due to a different kinetic behaviour of ADQ than that of Chloroquine