Clinical trials in Jamaica with the cendehill rubella vaccine - abstract

ABSTRACT

This paper presents our findings from a closed study involving 54 children, a family study involving 100 families and an open study involving more than 16,000 children, ages five years to 15 years, in an urban area in Jamaica. The vaccine produced good immunogenic response and did not spread the disease to susceptible controls in contact with the vaccinees. Our experience with the Cendehill rubella vaccine has shown that it has all the requirements of an acceptable vaccine. It produced sero-conversion in a large percentage of sero-negative vaccinees; it did not spread the disease to sero negative controls living in close contact; it produced only mild side effects in childern, and there was no evidence of arthralgia or arthritiis in vaccinees(AU)