The influence of changes in dietary regimen on spontaneous tumours of the pituitary gland in rats

ABSTRACT

Our findings firmly establish that the nutrition of early life does have long lasting effects and can also influence the incidence of disease later in life. This will be discussed and demonstrated for chromophobe adenoma's of the pituitary gland. These were seen in relatively high frequency in animals on ad libitum feeding. The incidence in animals on restricted food intake dropped sharply. Again changing the dietary regimen at 70 days of age from ad libitum to restricted feeding or vice versa markedly influenced the incidence of these tumours (AU)