Intramyometrial vasopressin as a haemostatic agent during myomectomy
Br J Obstet Gynaecol
; 101(5): 435-7, May 1994.
Article
in English
| MedCarib
| ID: med-7727
Responsible library:
JM3.1
Localization: JM3.1; RG1.J66
ABSTRACT
OBJECTIVE:
To assess the efficacy of intramyometrical vasopressin for minimising bleeding and its sequelae at myomectomy.DESIGN:
A randomised placebo controlled trial.SETTING:
University Hospital of the West Indies, Kingston, Jamaica.SUBJECTS:
Twenty women with symptomatic uterine fibroids scheduled for myomectomy who satisfied entry criteria 10 randomised to the vasopressin group and 10 to the control group. INTERVENTION Myomectomy was performed after the intramyometrial injection of either 20 units vasopressin diluted to 20 ml in normal saline or placebo (20 ml normal saline). MAIN OUTCOMEMEASURES:
The efficacy of vasopressin was measured by comparing pre- and post-operative haemoglobin levels and haematocrit, changes in intra-operative pulse and blood pressure, measured blood loss, need for blood transfusion post-operative febril morbidity in the treatment and control groups.RESULTS:
The use of vasopressin resulted in median blood loss of 225 ml (range150-400ml) compared with 675 ml (range 500-800ml) in the placebo group (p<0.001). The vasopressin group had a correspondingly lower fall in haemoglobin level (median 1.7g/dl vs 5.3g/dl, P<0.001) and haematocrit (median 5 percent vs 13 percent, P<0.001) compared with the controls. Fifty percent of the placebo group had blood transfusions compared with none in the vasopressin group (P=0.03). There were no significant differences between the groups in intra-operative pulse and blood pressure or post-operative white blood cell counts or temperature.CONCLUSION:
The results indicate that vasopressin is effective in preventing blood loss and reducing the need for blood transfusion during myomectomy (AU)
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Collection:
International databases
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
MedCarib
Main subject:
Uterine Neoplasms
/
Vasopressins
/
Hemostasis, Surgical
/
Leiomyoma
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Br J Obstet Gynaecol
Year:
1994
Document type:
Article