Congenital yellow fever virus infection after immunization in pregnancy
J Infect Dis
; 168(6): 1520-3, Dec. 1993.
Article
in English
| MedCarib
| ID: med-8336
Responsible library:
JM3.1
Localization: JM3.1; R11.J71
ABSTRACT
To determine whether yellow fever (YF) vaccine administered in pregnancy causes fetal infection, women who were vaccinated during unrecognized pregnancy in a mass campaign in Trinidad were studied retrospectively. Maternal and cord or infant blood were tested for IgM and neutralizing antibodies to YF virus, indicating congenital infection. The infant, the first repotred case of YF virus infection after immunization in prgnancy, was delivered after an uncomplicated full-term pregnancy and appeared normal. Congenital dengue 1 infection may have occurred in another case. The frequency of fetal infection and adverse events after such exposure could not be estimated; however, the neurotropism of YF virus for the developing nervous system and the now documented possibility of trans-placental infection underscores the admonition that YF vaccination in pregnancy should be avoided (AU)
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Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Dengue
/
Neglected Diseases
Database:
MedCarib
Main subject:
Yellow Fever
/
Viral Vaccines
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Country/Region as subject:
English Caribbean
/
Trinidad and Tobago
Language:
English
Journal:
J Infect Dis
Year:
1993
Document type:
Article