Molecular analysis of HIV-1 infection in Barbados
West Indian med. j
; 49(Suppl 2): 3, Apr. 2000.
Article
in English
| MedCarib
| ID: med-996
Responsible library:
JM3.1
Localization: JM3.1; R18.W4
ABSTRACT
OBJECTIVE:
To determine the sub-type(s) of HIV-1 in patients with advanced disease in Barbados. DESIGN ANDMETHODS:
A molecular analysis was performed in sequences obtained from 38 HIV-1 infected persons. A 375 base pair fragment was amplified from the V3 loop of the env region of the HIV genome, using a nested RT-PCR method. The resulting fragment was sequenced directly and alignment was performed using the BLAST (Basic Local Alignment Search Tool) search.RESULTS:
Of 38 patients with advanced HIV-1 infection, all were found to be infected with HIV-1 subtype B, which closely relates to a similar subtype found in North America and Europe. This is the first time that HIV subtypes have been described from Barbadian patients with advanced HIV disease.CONCLUSIONS:
Our findings support the hypothesis that HIV infection in Barbados was derived initially from North America and Europe, where type B HIV infection is most common. Moreover, these findings indicate that vaccines suitable for use in North America will probably be effective in our population.(Au)
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Collection:
International databases
Database:
MedCarib
Main subject:
Acquired Immunodeficiency Syndrome
/
Molecular Epidemiology
Limits:
Humans
Country/Region as subject:
Barbados
/
English Caribbean
Language:
English
Journal:
West Indian med. j
Year:
2000
Document type:
Article