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Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer
Zhao Cai; Yumei Liu; XiangKe Duan; Shuhong Han; Yuao Zhu; Yingdan Zhang; Chao Zhuo; Yang Liu; Liang Yang.
Affiliation
  • Zhao Cai; School of Medicine, Southern University of Science and Technology
  • Yumei Liu; School of Medicine, Southern University of Science and Technology
  • XiangKe Duan; School of Medicine, Southern University of Science and Technology
  • Shuhong Han; School of Medicine, Southern University of Science and Technology
  • Yuao Zhu; School of Medicine, Southern University of Science and Technology
  • Yingdan Zhang; School of Medicine, Southern University of Science and Technology
  • Chao Zhuo; The state key laboratory of respiratory diseases, the first affiliated hospital of Guangzhou Medical University
  • Yang Liu; Medical Research Center, Southern University of Science and Technology Hospital, 518055, Shenzhen, China
  • Liang Yang; School of Medicine, Southern University of Science and Technology
Preprint in English | bioRxiv | ID: ppbiorxiv-238998
ABSTRACT
This study characterized a genetically adapted Pseudomonas aeruginosa small colony variant isolated from a COVID-19 patient who suffered persistent bacterial coinfection and eventually recovered from critical illness. Specification and modification of the isolates discovered at genomic and transcriptomic levels with aligned phenotypic observations indicated that these isolates formed excessive biofilm with elevated quorum sensing systems.
License
cc_by_nc
Full text: Available Collection: Preprints Database: bioRxiv Type of study: Observational study / Prognostic study Language: English Year: 2020 Document type: Preprint
Full text: Available Collection: Preprints Database: bioRxiv Type of study: Observational study / Prognostic study Language: English Year: 2020 Document type: Preprint
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