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A novel SARS-CoV-2 related coronavirus in bats from Cambodia
Vibol Hul; Deborah Delaune; Erik A. Karlsson; Alexandre Hassanin; Putita Ou Tey; Artem Baidaliuk; Fabiana Gambaro; Vuong Tan Tu; Lucy Keatts; Jonna Mazet; Christine Johnson; Philippe Buchy; Philippe Dussart; Tracey Goldstein; Etienne Simon-Loriere; Veasna Duong.
Affiliation
  • Vibol Hul; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  • Deborah Delaune; Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France.
  • Erik A. Karlsson; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  • Alexandre Hassanin; Institut de Systematique, evolution, Biodiversite, Sorbonne Universite, MNHN, CNRS, EPHE, UA, Paris, France.
  • Putita Ou Tey; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  • Artem Baidaliuk; Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France.
  • Fabiana Gambaro; Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France.
  • Vuong Tan Tu; Institut de Systematique, evolution, Biodiversite, Sorbonne Universite, MNHN, CNRS, EPHE, UA, Paris, France.
  • Lucy Keatts; Wildlife Conservation Society, Health Program, Bronx, NY, USA.
  • Jonna Mazet; One Health Institute, School of Veterinary Medicine, University of California, Davis, USA
  • Christine Johnson; One Health Institute, School of Veterinary Medicine, University of California, Davis, USA
  • Philippe Buchy; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  • Philippe Dussart; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  • Tracey Goldstein; One Health Institute, School of Veterinary Medicine, University of California, Davis, USA
  • Etienne Simon-Loriere; Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France.
  • Veasna Duong; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Preprint in English | bioRxiv | ID: ppbiorxiv-428212
Journal article
A scientific journal published article is available and is probably based on this preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled in the Yunnan province, China. Here we describe the identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010. Metagenomic sequencing identified nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely related to SARS-CoV-2, with the exception of a small region corresponding to the spike N terminal domain. The discovery of these viruses in a bat species not found in China indicates that SARS-CoV-2 related viruses have a much wider geographic distribution than previously understood, and suggests that Southeast Asia represents a key area to consider in the ongoing search for the origins of SARS-CoV-2, and in future surveillance for coronaviruses.
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Full text: Available Collection: Preprints Database: bioRxiv Language: English Year: 2021 Document type: Preprint
Fulltext
Add to My VHL
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XML
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Full text: Available Collection: Preprints Database: bioRxiv Language: English Year: 2021 Document type: Preprint