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Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants
Jinbiao Liu; Brittany H Bodnar; Xu Wang; Peng Wang; Fengzhen Meng; Adil I Khan; A Sami Saribas; Nigam H Padhiar; Elizabeth McCluskey; Sahil Shah; Jin Jun Luo; Wenhui Hu; Wen-Zhe Ho.
Affiliation
  • Jinbiao Liu; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • Brittany H Bodnar; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19141, USA; Center for Metabolic Disease Rese
  • Xu Wang; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • Peng Wang; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • Fengzhen Meng; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • Adil I Khan; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • A Sami Saribas; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19141, USA; Center for Metabolic Disease Rese
  • Nigam H Padhiar; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • Elizabeth McCluskey; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • Sahil Shah; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19141, USA; Center for Metabolic Disease Rese
  • Jin Jun Luo; Department of Neurology, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
  • Wenhui Hu; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19141, USA; Center for Metabolic Disease Rese
  • Wen-Zhe Ho; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA
Preprint in En | PREPRINT-BIORXIV | ID: ppbiorxiv-445871
Journal article
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ABSTRACT
Both Pfizer-BNT162b2 and Moderna-mRNA-1273 vaccines can elicit an effective immune response against SARS-CoV-2 infection. However, the elicited serum antibody levels vary substantially and longitudinally decrease after vaccination. We examined the correlation of vaccination-induced IgG levels and neutralization titers against newly emerged variants remains and demonstrate a significant reduction of neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351) in Pfizer or Moderna vaccined sera. There was a significant and positive correlation between serum IgG levels and ID50 titers for not only SARS-CoV-2 WT but also the variants. These findings indicate that a high level of anti-spike IgG may offer better protection against infection from SARS-CoV-2 and its variants. Therefore, it is necessary to longitudinally monitor specific serum IgG level for evaluating the protective efficacy of the vaccines against SARS-CoV-2 and its new variants.
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Full text: 1 Collection: 09-preprints Database: PREPRINT-BIORXIV Type of study: Experimental_studies Language: En Year: 2021 Document type: Preprint
Fulltext
Add to My VHL
Print
XML
Search on Google
Full text: 1 Collection: 09-preprints Database: PREPRINT-BIORXIV Type of study: Experimental_studies Language: En Year: 2021 Document type: Preprint