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Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
Li Wang; Markus H Kainulainen; Nannan Jiang; Han Di; Gaston Bonenfant; Lisa Mills; Michael Currier; Punya Shrivastava-Ranjan; Brenda M Calderon; Mili Sheth; Brian R Mann; Jaber Hossain; Xudong Lin; Sandra Lester; Elizabeth Pusch; Joyce Jones; Dan Cui; Payel Chatterjee; Harley M Jenks; Esther Morantz; Gloria Larson; Masato Hatta; Jennifer Harcourt; Azaibi Tamin; Yan Lin; Ying Tao; Kun Zhao; Kristine Lacek; Ashely Burroughs; Terianne Wong; Suxiang Tong; John R Barnes; Mark W Tenforde; Wesley H Self; Nathan I Shapiro; Matthew C Exline; D. Clark Files; Kevin W Gibbs; David N Hager; Manish Patel; Alison S Laufer Halpin; Laura K McMullan; Justin S Lee; Hongjie Xia; Xuping Xie; Pei-Yong Shi; C. Todd Davis; Christina F Spiropoulou; Natalie J. Thornburg; M. Steven Oberste; Vivien Dugan; - SSEV Bioinformatics Working Group; David E Wentworth; Bin Zhou.
Affiliation
  • Li Wang; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Markus H Kainulainen; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Nannan Jiang; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Han Di; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Gaston Bonenfant; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Lisa Mills; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Michael Currier; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Punya Shrivastava-Ranjan; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Brenda M Calderon; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Mili Sheth; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Brian R Mann; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Jaber Hossain; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Xudong Lin; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Sandra Lester; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Elizabeth Pusch; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Joyce Jones; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Dan Cui; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Payel Chatterjee; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Harley M Jenks; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Esther Morantz; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Gloria Larson; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Masato Hatta; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Jennifer Harcourt; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Azaibi Tamin; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Yan Lin; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Ying Tao; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Kun Zhao; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Kristine Lacek; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Ashely Burroughs; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Terianne Wong; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Suxiang Tong; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • John R Barnes; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Mark W Tenforde; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Wesley H Self; Vanderbilt University, Nashville, Tennessee, USA
  • Nathan I Shapiro; Harvard University, Cambridge, Massachusetts, USA
  • Matthew C Exline; Ohio State University, Columbus, Ohio, USA
  • D. Clark Files; Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA
  • Kevin W Gibbs; Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA
  • David N Hager; Johns Hopkins University, Baltimore, Maryland, USA
  • Manish Patel; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Alison S Laufer Halpin; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Laura K McMullan; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Justin S Lee; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Hongjie Xia; The University of Texas Medical Branch at Galveston, Texas
  • Xuping Xie; The University of Texas Medical Branch at Galveston, Texas
  • Pei-Yong Shi; The University of Texas Medical Branch at Galveston, Texas
  • C. Todd Davis; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Christina F Spiropoulou; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Natalie J. Thornburg; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • M. Steven Oberste; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Vivien Dugan; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • - SSEV Bioinformatics Working Group; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • David E Wentworth; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Bin Zhou; COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Preprint in En | PREPRINT-BIORXIV | ID: ppbiorxiv-469906
ABSTRACT
IntroductoryThe evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of many new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were designated as variants of concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact on vaccines. To ascertain and rank the risk of VOCs and VOIs, we analyzed their ability to escape from vaccine-induced antibodies. The variants showed differential reductions in neutralization and replication titers by post-vaccination sera. Although the Omicron variant showed the most escape from neutralization, sera collected after a third dose of vaccine (booster sera) retained moderate neutralizing activity against that variant. Therefore, vaccination remains the most effective strategy to combat the COVID-19 pandemic.
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Full text: 1 Collection: 09-preprints Database: PREPRINT-BIORXIV Type of study: Prognostic_studies Language: En Year: 2021 Document type: Preprint
Fulltext
Add to My VHL
Print
XML
Search on Google
Full text: 1 Collection: 09-preprints Database: PREPRINT-BIORXIV Type of study: Prognostic_studies Language: En Year: 2021 Document type: Preprint