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Modeling suggests that multiple immunizations or infections will reveal the benefits of updating SARS-CoV-2 vaccines
Preprint
in English
| bioRxiv
| ID: ppbiorxiv-492928
ABSTRACT
When should vaccines to evolving pathogens such as SARS-CoV-2 be updated? Our computational models address this focusing on updating SARS-CoV-2 vaccines to the currently circulating Omicron variant. Current studies typically compare the antibody titers to the new variant following a single dose of the original-vaccine versus the updated-vaccine in previously immunized individuals. These studies find that the updated-vaccine does not induce higher titers to the vaccine-variant compared with the original-vaccine, suggesting that updating may not be needed. Our models recapitulate this observation but suggest that vaccination with the updated-vaccine generates qualitatively different humoral immunity, a small fraction of which is specific for unique epitopes to the new variant. Our simulations suggest that these new variant-specific responses could dominate following subsequent vaccination or infection with either the currently circulating or future variants. We suggest a two-dose strategy for determining if the vaccine needs updating and for vaccinating high-risk individuals.
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Full text:
Available
Collection:
Preprints
Database:
bioRxiv
Type of study:
Observational study
/
Prognostic study
/
Qualitative research
Language:
English
Year:
2022
Document type:
Preprint