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Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine
Preprint
in English
| bioRxiv
| ID: ppbiorxiv-951939
ABSTRACT
A recombinant adenovirus vaccine against the SARS Coronavirus (SARS-CoV) was constructed, which contains fragments from the S, N, and Orf8 genes. Rhesus Macaques immunized with the recombinant adenovirus generated antigen-specific humoral and cellular response. Furthermore, the vaccine provided significant protection against subsequent live SARS-CoV challenge. In contrast, three out of four monkeys immunized with placebo suffered severe alveolar damage and pulmonary destruction.
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Full text:
Available
Collection:
Preprints
Database:
bioRxiv
Type of study:
Rct
Language:
English
Year:
2020
Document type:
Preprint