Insights into the Mechanism of Ethionamide Resistance in Mycobacterium tuberculosis through an in silico Structural Evaluation of EthA and Mutants Identified in Clinical Isolates

Souza, Vinicius Carius de; Antunes, Deborah; Santos, Lucianna H. S.; Goliatt, Priscila Vanessa Zabala Capriles; Caffarena, Ernesto Raul; Guimarães, Ana Carolina Ramos; Galvão, Teca Calcagno

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Insights into the Mechanism of Ethionamide Resistance in Mycobacterium tuberculosis through an in silico Structural Evaluation of EthA and Mutants Identified in Clinical Isolates

Souza, Vinicius Carius de; Antunes, Deborah; Santos, Lucianna H. S.; Goliatt, Priscila Vanessa Zabala Capriles; Caffarena, Ernesto Raul; Guimarães, Ana Carolina Ramos; Galvão, Teca Calcagno.

Affiliation

Souza, Vinicius Carius de; Universidade Federal de Juiz de Fora. Programa de Pós-graduação em Modelagem Computacional. Juiz de Fpra, MG, Brasil..

Preprint in English | Fiocruz Preprints | ID: ppf-42455

Ethionamide; Resistência à ethionamida; Dinâmica molecular; Integração termodinâmica; EthA; Ethionamide resistance; BVMO; Molecular dynamics; Thermodynamic integration

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