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Clinical findings in critical ill patients infected with SARS-Cov-2 in Guangdong Province, China: a multi-center, retrospective, observational study
Yonghao Xu; Zhiheng Xu; Xuesong Liu; Lihua Cai; Haichong Zheng; Yongbo Huang; Lixin Zhou; Linxi Huang; Yun Lin; Liehua Deng; Jianwei Li; Sibei Chen; Dongdong Liu; Zhimin Lin; Liang Zhou; Weiqun He; Xiaoqing Liu; Yimin Li.
Affiliation
  • Yonghao Xu; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Zhiheng Xu; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Xuesong Liu; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Lihua Cai; Dongguan People's Hospital, Department of Intensive Care
  • Haichong Zheng; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Yongbo Huang; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Lixin Zhou; Foshan First People's Hospital, Department of Intensive Care
  • Linxi Huang; The First Affiliated Hospital of Shantou University Medical College, Department of Intensive Care
  • Yun Lin; Huizhou Municipal Central Hospital, Department of Intensive Care
  • Liehua Deng; Affiliated Hospital of Guangdong Medical University, Department of Intensive Care
  • Jianwei Li; Zhongshan City People's Hospital, Department of Intensive Care
  • Sibei Chen; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Dongdong Liu; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Zhimin Lin; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Liang Zhou; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Weiqun He; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Xiaoqing Liu; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
  • Yimin Li; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Department o
Preprint in En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20030668
ABSTRACT
BackgroundIn December 2019, human infection with a novel coronavirus, known as SARS-CoV-2, was identified in Wuhan, China. The mortality of critical illness was high in Wuhan. Information about critically ill patients with SARS-CoV-2 infection outside of Wuhan is scarce. We aimed to provide the clinical features, treatment, and prognosis of the critically ill patients with SARS-CoV-2 infection in Guangdong Province. MethodsIn this multi-centered, retrospective, observational study, we enrolled critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) in Guangdong Province. Demographic data, symptoms, laboratory findings, comorbidities, treatments, and prognosis were collected. Data were compared between patients with and without intubation. ResultsForty-five critically ill patients with SARS-CoV-2 pneumonia were identified in 7 ICUs in Guangdong Province. The mean age was 56.7 years, and 29 patients (64.4%) were men. The most common symptoms at the onset of illness were high fever and cough. Majority of patients presented with lymphopenia and elevated lactate dehydrogenase. Treatment with antiviral drugs was initiated in all the patients. Thirty-seven patients (82.2%) had developed acute respiratory distress syndrome, and 13 (28.9%) septic shock. A total of 20 (44.4%) patients required intubation and 9 (20%) required extracorporeal membrane oxygenation. As of February 28th 2020, only one patient (2.2%) had died and half of them had discharged of ICU. ConclusionsInfection with SARS-CoV-2 in critical illness is characterized by fever, lymphopenia, acute respiratory failure and multiple organ dysfunction. Compared with critically ill patients infected with SARS-CoV-2 in Wuhan, the mortality of critically ill patients in Guangdong Province was relatively low. These data provide some general understandings and experience for the critical patients with SARS-CoV-2 outside of Wuhan.
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Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Type of study: Observational_studies / Prognostic_studies Language: En Year: 2020 Document type: Preprint
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Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Type of study: Observational_studies / Prognostic_studies Language: En Year: 2020 Document type: Preprint