Your browser doesn't support javascript.
loading
The clinical characteristics and mortal causes analysis of COVID-19 death patients
Ao-Xiang Guo; Jia-Jia Cui; Qian-Ying OuYang; Li He; Cheng-Xian Guo; Ji-Ye Yin.
Affiliation
  • Ao-Xiang Guo; Department of Clinical Pharmacology, Xiangya Hospital, Central South University
  • Jia-Jia Cui; Department of Clinical Pharmacology, Xiangya Hospital, Central South University
  • Qian-Ying OuYang; Department of Clinical Pharmacology, Xiangya Hospital, Central South University
  • Li He; Department of Pediatrics, The Third Xiangya Hospital, Central South University
  • Cheng-Xian Guo; Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University
  • Ji-Ye Yin; Department of Clinical Pharmacology, Xiangya Hospital, Central South University
Preprint in English | medRxiv | ID: ppmedrxiv-20062380
ABSTRACT
PurposeCurrently, COVID-19 is causing a large number of deaths globally. However, few researches focused on the clinical features of death patients. This study conducted a retrospective analysis of clinical characteristics and mortal causes in Chinese COVID-19 death patients. Patients and methodsThe clinical characteristics of death patients were collected from publicized by local health authorities in China. Expressions of virus targets in human organs were obtained from GTEx database. Results159 patients from 24 provinces in China were recruited in our study, including 26 young patients under 60 and 133 aged 60 or older. The median age was 71 years, which indicated that most death patients were elderly. More male patients died of COVID-19 than females (1.65 fold). Hypertension was the most common coexisting disorder and respiratory failure was the most common direct cause of death. Fever (71.19%) and cough (55.08%) were the predominant presenting symptoms. There was one asymptomatic patient. In addition, by comparing young and old patients, heart disease was identified as an important risk factor for death in the aged patients. ACE2 and TMPRSS2 were the targets of SARS-CoV-2, we analyzed their expression in different organs. TMPRSS2 and ACE2 had a high expression in the organs which had corresponding clinical features in death patients. ConclusionMale, age and heart disease were the main risk factors of death. Beside, asymptomatic patients with serious coexisting disorders may also die of SARS-CoV-2. Thus, more attention should be paid to the old patients with heart disease and asymptomatic patients in the treatment.
License
cc_by_nc_nd
Full text: Available Collection: Preprints Database: medRxiv Type of study: Observational study / Prognostic study Language: English Year: 2020 Document type: Preprint
Full text: Available Collection: Preprints Database: medRxiv Type of study: Observational study / Prognostic study Language: English Year: 2020 Document type: Preprint
...