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Placental pathology in COVID-19
Preprint
in English
| medRxiv
| ID: ppmedrxiv-20093229
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A scientific journal published article is available and is probably based on this preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
ObjectivesTo describe histopathologic findings in the placentas of women with COVID-19 during pregnancy. MethodsPregnant women with COVID-19 delivering between March 18, 2020 and May 5, 2020 were identified. Placentas were examined and compared to historical controls and women with placental evaluation for a history of melanoma. Results16 placentas from patients with SARS-CoV-2 were examined (15 with live birth in the 3rd trimester 1 delivered in the 2nd trimester after intrauterine fetal demise). Compared to controls, third trimester placentas were significantly more likely to show at least one feature of maternal vascular malperfusion (MVM), including abnormal or injured maternal vessels, as well as delayed villous maturation, chorangiosis, and intervillous thrombi. Rates of acute and chronic inflammation were not increased. The placenta from the patient with intrauterine fetal demise showed villous edema and a retroplacental hematoma. ConclusionsRelative to controls, COVID-19 placentas show increased prevalence of features of maternal vascular malperfusion (MVM), a pattern of placental injury reflecting abnormalities in oxygenation within the intervillous space associated with adverse perinatal outcomes. Only 1 COVID-19 patient was hypertensive despite the association of MVM with hypertensive disorders and preeclampsia. These changes may reflect a systemic inflammatory or hypercoagulable state influencing placental physiology. Key PointsO_LIThe placentas of women infected with SARS-CoV2 have higher rates maternal vascular malperfusion features compared to controls. C_LIO_LIMaternal vascular malperfusion has been associated with adverse perinatal outcomes, such as preeclampsia, fetal growth restriction, preterm birth, and stillbirth. C_LIO_LIAs the placentas of women with SARS-CoV2 show reproducible histopathologic abnormalities, these findings suggest increased antenatal surveillance for women with COVID-19 may be warranted. C_LI
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Full text:
Available
Collection:
Preprints
Database:
medRxiv
Type of study:
Experimental_studies
/
Observational study
/
Prognostic study
Language:
English
Year:
2020
Document type:
Preprint