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A novel sample pooling strategy and its application for mass screening of SARS-CoV-2 in an outbreak of COVID-19 in Vietnam
Ton That Thanh; Nguyen Thi Thanh Nhan; Huynh Kim Mai; Nguyen Bao Trieu; Le Xuan Huy; Ho Thi Thanh Thuy; Le Thanh Chung; Nguyen Ngoc Anh; Nguyen Thi Thu Hong; Bui Duc Thang; Nguyen Thi Hoai Thu; Le Thi Kim Chi; Nguyen Thi Hanh; Nguyen Huy Hoang; Chau Nguyen; Guy Thwaites; Do Thai Hung; Le Van Tan; Ngo Thi Kim Yen.
Affiliation
  • Ton That Thanh; Da Nang CDC, Vietnam
  • Nguyen Thi Thanh Nhan; Da Nang CDC, Vietnam
  • Huynh Kim Mai; IP, Nha Trang, Vietnam
  • Nguyen Bao Trieu; IP, Nha Trang, Vietnam
  • Le Xuan Huy; IP, Nha Trang, Vietnam
  • Ho Thi Thanh Thuy; Viet A, Vietnam
  • Le Thanh Chung; Da Nang CDC, Vietnam
  • Nguyen Ngoc Anh; Da Nang CDC, Vietnam
  • Nguyen Thi Thu Hong; OUCRU, Vietnam
  • Bui Duc Thang; Da Nang CDC, Vietnam
  • Nguyen Thi Hoai Thu; Da Nang CDC, Vietnam
  • Le Thi Kim Chi; Da Nang CDC, Vietnam
  • Nguyen Thi Hanh; Da Nang University of Medical Technology and Pharmacy, Da Nang city, Vietnam
  • Nguyen Huy Hoang; Da Nang University of Medical Technology and Pharmacy, Da Nang city, Vietnam
  • Chau Nguyen; Hospital for Tropical Diseases
  • Guy Thwaites; OUCRU, Vietnam
  • Do Thai Hung; IP, Nha Trang, Vietnam
  • Le Van Tan; OUCRU-VN
  • Ngo Thi Kim Yen; DoH, Da Nang, Vietnam
Preprint in English | medRxiv | ID: ppmedrxiv-20192484
ABSTRACT
We present a sample pooling approach and the results of its application for mass screening of SARS-CoV-2 in >96,000 asymptomatic individuals. Our approach did not compromise the sensitivity of PCR, while increasing the throughput and reducing 77% of the costs. 22/32 asymptomatic cases would have been missed without mass screening.
License
cc_by
Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2020 Document type: Preprint
Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2020 Document type: Preprint
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