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Novel prognostic determinants of COVID-19-related mortality: a pilot study on severely-ill patients in Russia
Kseniya A. Rubina Dr.; Anna A. Shmakova Dr.; Aslan K. Shabanov Dr.; Yulii V. Andreev Dr.; Natalia V. Borovkova Dr.; Vladimir V. Kulabukhov Dr.; Anatoliy K. Evseev Dr.; Konstantin A. Popugaev Dr.; Sergey S. Petrikov Dr.; Ekaterina V. Semina Dr..
Affiliation
  • Kseniya A. Rubina Dr.; Laboratory of Morphogenesis and Tissue Reparation, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russian Federation
  • Anna A. Shmakova Dr.; Laboratory of Molecular Endocrinology, Institute of Experimental Cardiology, Federal State Budgetary Organization National Cardiology Research Center Ministry o
  • Aslan K. Shabanov Dr.; Department of Intensive Care, Sklifosovsky Research Institute of Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation
  • Yulii V. Andreev Dr.; Department of Intensive Care, Sklifosovsky Research Institute of Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation
  • Natalia V. Borovkova Dr.; Department of Intensive Care, Sklifosovsky Research Institute of Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation
  • Vladimir V. Kulabukhov Dr.; Department of Intensive Care, Sklifosovsky Research Institute of Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation
  • Anatoliy K. Evseev Dr.; Department of Intensive Care, Sklifosovsky Research Institute of Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation
  • Konstantin A. Popugaev Dr.; Department of Intensive Care, Sklifosovsky Research Institute of Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation
  • Sergey S. Petrikov Dr.; Department of Intensive Care, Sklifosovsky Research Institute of Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation
  • Ekaterina V. Semina Dr.; Laboratory of Molecular Endocrinology, Institute of Experimental Cardiology, Federal State Budgetary Organization National Cardiology Research Center Ministry o
Preprint in English | medRxiv | ID: ppmedrxiv-21254688
ABSTRACT
COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment. FundingThe reported study was funded by RFBR according to the research project [numero] 20-24-60029.
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort_studies / Observational study / Prognostic study Language: English Year: 2021 Document type: Preprint
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort_studies / Observational study / Prognostic study Language: English Year: 2021 Document type: Preprint