Protection of previous SARS-CoV-2 infection is similar to that of BNT162b2 vaccine protection: A three-month nationwide experience from Israel

ABSTRACT

Worldwide shortage of vaccination against SARS-CoV-2 infection while the pandemic is still uncontrolled leads many states to the dilemma whether or not to vaccinate previously infected persons. Understanding the level of protection of previous infection compared to that of vaccination is critical for policy making. We analyze an updated individual-level database of the entire population of Israel to assess the protection efficacy of both prior infection and vaccination in preventing subsequent SARS-CoV-2 infection, hospitalization with COVID-19, severe disease, and death due to COVID-19. Vaccination was highly effective with overall estimated efficacy for documented infection of 92{middle dot}8% (CI[92{middle dot}6, 93{middle dot}0]); hospitalization 94{middle dot}2% (CI[93{middle dot}6, 94{middle dot}7]); severe illness 94{middle dot}4% (CI[93{middle dot}6, 95{middle dot}0]); and death 93{middle dot}7% (CI[92{middle dot}5, 94{middle dot}7]). Similarly, the overall estimated level of protection from prior SARS-CoV-2 infection for documented infection is 94{middle dot}8% (CI[94{middle dot}4, 95{middle dot}1]); hospitalization 94{middle dot}1% (CI[91{middle dot}9, 95{middle dot}7]); and severe illness 96{middle dot}4% (CI[92{middle dot}5, 98{middle dot}3]). Our results question the need to vaccinate previously-infected individuals.