Variants of concern are overrepresented among post-vaccination breakthrough infections of SARS-CoV-2 in Washington State

Abbye E McEwen; Seth Cohen; Chloe Bryson-Cahn; Catherine Liu; Steven A Pergam; John Lynch; Adrienne Schippers; Kathy Strand; Estella Whimbey; Nandita S Mani; Allison J Zellikoff; Vanessa A Makarewicz; Elizabeth R Brown; Shah A Mohamed Bakhash; Noah R Baker; Jared Castor; Robert J Livingston; Meei-Li Huang; Keith R Jerome; Alexander L Greninger; Pavitra Roychoudhury

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Variants of concern are overrepresented among post-vaccination breakthrough infections of SARS-CoV-2 in Washington State

Abbye E McEwen; Seth Cohen; Chloe Bryson-Cahn; Catherine Liu; Steven A Pergam; John Lynch; Adrienne Schippers; Kathy Strand; Estella Whimbey; Nandita S Mani; Allison J Zellikoff; Vanessa A Makarewicz; Elizabeth R Brown; Shah A Mohamed Bakhash; Noah R Baker; Jared Castor; Robert J Livingston; Meei-Li Huang; Keith R Jerome; Alexander L Greninger; Pavitra Roychoudhury.

Affiliation

Abbye E McEwen; University of Washington
Seth Cohen; University of Washington
Chloe Bryson-Cahn; University of Washington
Catherine Liu; Fred Hutchinson Cancer Research Center
Steven A Pergam; Fred Hutchinson Cancer Research Center
John Lynch; University of Washington
Adrienne Schippers; University of Washington Medical Center
Kathy Strand; University of Washington Medical Center
Estella Whimbey; University of Washington
Nandita S Mani; University of Washington
Allison J Zellikoff; University of Washington
Vanessa A Makarewicz; University of Washington
Elizabeth R Brown; Fred Hutchinson Cancer Research Center
Shah A Mohamed Bakhash; University of Washington
Noah R Baker; University of Washington
Jared Castor; University of Washington
Robert J Livingston; University of Washington
Meei-Li Huang; University of Washington
Keith R Jerome; University of Washington
Alexander L Greninger; University of Washington
Pavitra Roychoudhury; University of Washington

Preprint in English | medRxiv | ID: ppmedrxiv-21257679

Journal article
A scientific journal published article is available and is probably based on this preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT

ABSTRACT

Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOC) and had a median Ct of 20.2 (IQR=17.1-23.3). When compared to 5174 contemporaneous samples sequenced in our laboratory, VOC were significantly enriched among breakthrough infections (p < .05).

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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2021 Document type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2021 Document type: Preprint