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New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations
Frauke Degenhardt; David Ellinghaus; Simonas Juzenas; Jon Lerga-Jaso; Mareike Wendorff; Douglas Maya-Miles; Florian Uellendahl-Werth; Hesham ElAbd; Malte Christoph Ruehlemann; Jatin Arora; Onur Oezer; Ole Bernt Lenning; Ronny Myhre; May Sissel Vadla; Eike Matthias Wacker; Lars Wienbrandt; Aaron Blandino Ortiz; Adolfo de Salazar; Adolfo Garrido Chercoles; Adriana Palom; Agustin Ruiz; Alba-Estela Garcia-Fernandez; Albert Blanco-Grau; Alberto Mantovani; Alberto Zanella; Aleksander Rygh Holten; Alena Mayer; Alessandra Bandera; Alessandro Cherubini; Alessandro Protti; Alessio Aghemo; Alessio Gerussi; Alfredo Ramirez; Alice Braun; Almut Nebel; Ana Barreira; Ana Lleo; Ana Teles; Anders Kildal; Andrea Biondi; Andrea Caballero-Garralda; Andrea Ganna; Andrea Gori; Andreas Glueck; Andreas Lind; Anja Tanck; Anke Hinney; Anna Carreras Carreras Nolla; Anna Ludovica Fracanzani; Anna Peschuck; Annalisa Cavallero; Anne Ma Dyrhol-Riise; Antonella Ruello; Antonio Julia; Antonio Muscatello; Antonio Pesenti; Antonio Voza; Ariadna Rando-Segura; Aurora Solier; Axel Schmidt; Beatriz Cortes; Beatriz Mateos; Beatriz Nafria-Jimenez; Benedikt Schaefer; Bjoern Jensen; Carla Bellinghausen; Carlo Maj; Carlos Ferrando; Carmen de la Horra; Carmen Quereda; Carsten Skurk; Charlotte Thibeault; Chiara Scollo; Christian Herr; Christoph D Spinner; Christoph Gassner; Christoph Lange; Cinzia Hu; Cinzia Paccapelo; Clara Lehmann; Claudio Angelini; Claudio Cappadona; Clinton Azuure; Cristiana Bianco; Cristina Cea; Cristina Sancho; Dag Arne Lihaug Hoff; Daniela Galimberti; Daniele Prati; David Haschka; David Jimenez; David Pestana; David Toapanta; Eduardo Muniz-Diaz; Elena Azzolini; Elena Sandoval; Eleonora Binatti; Elio Scarpini; Elisa T Helbig; Elisabetta Casalone; Eloisa Urrechaga; Elvezia Maria Paraboschi; Emanuele Pontali; Enric Reverter; Enrique J Calderon; Enrique Navas; Erik Solligard; Ernesto Contro; Eunate Arana-Arri; Fatima Aziz; Federico Garcia; Felix Garcia Sanchez; Ferruccio Ceriotti; Filippo Martinelli-Boneschi; Flora Peyvandi; Florian Kurth; Francesco Blasi; Francesco Malvestiti; Francisco J Medrano; Francisco Mesonero; Francisco Rodriguez-Frias; Frank Hanses; Fredrik Mueller; Georg Hemmrich-Stanisak; Giacomo Bellani; Giacomo Grasselli; Gianni Pezzoli; Giorgio Costantino; Giovanni Albano; Giulia Cardamone; Giuseppe Bellelli; Giuseppe Citerio; Giuseppe Foti; Giuseppe Lamorte; Giuseppe Matullo; Guido Baselli; Hayato Kurihara; Holger Neb; Ilaria My; Ingo Kurth; Isabel Hernandez; Isabell Pink; Itziar de Rojas; Ivan Galvan-Femenia; Jan Cato Holter; Jan Egil Afset; Jan Heyckendorf; Jan Kaessens; Jan Kristian Damas; Jan Rybniker; Janine Altmueller; Javier Ampuero; Javier Martin; Jeanette Erdmann; Jesus M Banales; Joan Ramon Badia; Joaquin Dopazo; Jochen Schneider; Jonas Bergan; Jordi Barretina; Joern Walter; Jose Hernandez Quero; Josune Goikoetxea; Juan Delgado; Juan M Guerrero; Julia Fazaal; Julia Kraft; Julia Schroeder; Kari Risnes; Karina Banasik; Karl Erik Mueller; Karoline I Gaede; Koldo Garcia-Etxebarria; Kristian Tonby; Lars Heggelund; Laura Izquierdo-Sanchez; Laura Rachele Bettini; Lauro Sumoy; Leif Erik Sander; Lena J Lippert; Leonardo Terranova; Lindokuhle Nkambule; Lisa Knopp; Lise Tuset Gustad; Lucia Garbarino; Luigi Santoro; Luis Tellez; Luisa Roade; Mahnoosh Ostadreza; Maider Intxausti; Manolis Kogevinas; Mar Riveiro-Barciela; Marco Schaefer; Mari EK Niemi; Maria A Gutierrez-Stampa; Maria Carrabba; Maria E Figuera Basso; Maria Grazia Valsecchi; Maria Hernandez-Tejero; Maria JGT Vehreschild; Maria Manunta; Marialbert Acosta-Herrera; Mariella D'Angio; Marina Baldini; Marina Cazzaniga; Marit M Grimsrud; Markus Cornberg; Markus M Noethen; Marta Marquie; Massimo Castoldi; Mattia Cordioli; Maurizio Cecconi; Mauro D'Amato; Max Augustin; Melissa Tomasi; Merce Boada; Michael Dreher; Michael J Seilmaier; Michael Joannidis; Michael Wittig; Michela Mazzocco; Michele Ciccarelli; Miguel Rodriguez-Gandia; Monica Bocciolone; Monica Miozzo; Natale Imaz-Ayo; Natalia Blay; Natalia Chueca; Nicola Montano; Nicole Braun; Nicole Ludwig; Nikolaus Marx; Nilda Martinez; Oliver A Cornely; Oliver Witzke; Orazio Palmieri; Paola Faverio; Paoletta Preatoni; Paolo Bonfanti; Paolo Omodei; Paolo Tentorio; Pedro Castro; Pedro M Rodrigues; Pedro Pablo Espana; Per Hoffmann; Philip Rosenstiel; Philipp Schommers; Phillip Suwalski; Raul de Pablo; Ricard Ferrer; Robert Bals; Roberta Gualtierotti; Rocio Gallego-Duran; Rosa Nieto; Rossana Carpani; Ruben Morilla; Salvatore Badalamenti; Sammra Haider; Sandra Ciesek; Sandra May; Sara Bombace; Sara Marsal; Sara Pigazzini; Sebastian Klein; Serena Pelusi; Sibylle Wilfling; Silvano Bosari; Sonja Volland; Soren Brunak; Soumya Raychaudhuri; Stefan Schreiber; Stefanie Heilmann-Heimbach; Stefano Aliberti; Stephan Ripke; Susanne Dudman; Tanja Wesse; Tenghao Zheng; Thomas Bahmer; Thomas Eggermann; Thomas Illig; Thorsten Brenner; Tomas Pumarola; Torsten Feldt; Trine Folseraas; Trinidad Gonzalez Cejudo; Ulf Landmesser; Ulrike Protzer; Ute Hehr; Valeria Rimoldi; Valter Monzani; Vegard Skogen; Verena Keitel; Verena Kopfnagel; Vicente Friaza; Victor Andrade; Victor Moreno; Wolfgang Albrecht; Wolfgang Peter; Wolfgang Poller; Xavier Farre; Xiaoli Yi; Xiaomin Wang; Yascha Khodamoradi; Zehra Karadeniz; Anna Latiano; Siegfried Goerg; Petra Bacher; Philipp Koehler; Florian Tran; Heinz Zoller; Eva C Schulte; Bettina Heidecker; Kerstin U Ludwig; Javier Fernandez; Manuel Romero-Gomez; Agustin Albillos; Pietro Invernizzi; Maria Buti; Stefano Duga; Luis Bujanda; Johannes R Hov; Tobias L Lenz; Rosanna Asselta; Rafael de Cid; Luca Valenti; Tom Hemming Karlsen; Mario Caceres; Andre Franke; - COVICAT study group; - Covid-19 Aachen Study (COVAS); - Pa COVID-19 Study Group; - The Humanitas COVID-19 Task Force; - The Humanitas Gavazzeni COVID-19 Task Force; - Norwegian SARS-CoV-2 Study group.
Affiliation
- Frauke Degenhardt; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- David Ellinghaus; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Simonas Juzenas; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Jon Lerga-Jaso; Institut de Biotecnologia i de Biomedicina, Universitat Autonoma de Barcelona, Bellaterra (Barcelona), Spain
- Mareike Wendorff; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Douglas Maya-Miles; Hospital Universitario Virgen del Rocio de Sevilla, Sevilla, Spain
- Florian Uellendahl-Werth; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Hesham ElAbd; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Malte Christoph Ruehlemann; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Jatin Arora; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Onur Oezer; Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Ploen, Germany
- Ole Bernt Lenning; Research Department, Stavanger University Hospital
- Ronny Myhre; Norwegian Institute of Public Health, Division of Health Data and Digitalization, Department of Genetics and Bioinformatics (HDGB) Oslo, Norway
- May Sissel Vadla; Randaberg Municipality, Norway
- Eike Matthias Wacker; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Lars Wienbrandt; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Aaron Blandino Ortiz; Department of Intensive Care, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of Alcala, Madrid, S
- Adolfo de Salazar; Ibs.Granada Instituto de Investigacion Biosanitaria, Granada, Spain
- Adolfo Garrido Chercoles; Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, Clinical Biochemistry Department, San Sebastian, Spain
- Adriana Palom; Vall d'Hebron Institut de Recerca (VHIR), Vall B24Hebron Hospital Universitari, Barcelona, Spain
- Agustin Ruiz; Research Center and Memory Clinic. Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain
- Alba-Estela Garcia-Fernandez; Department of Biochemistry, University Hospital Vall d'Hebron, Barcelona, Spain
- Albert Blanco-Grau; Department of Biochemistry, University Hospital Vall d'Hebron, Barcelona, Spain
- Alberto Mantovani; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Alberto Zanella; University of Milan, Milan, Italy
- Aleksander Rygh Holten; Department of Acute Medicine, Oslo University Hospital, Oslo, Norway
- Alena Mayer; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Alessandra Bandera; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Alessandro Cherubini; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Alessandro Protti; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Alessio Aghemo; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Alessio Gerussi; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy
- Alfredo Ramirez; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University
- Alice Braun; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Almut Nebel; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Ana Barreira; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain
- Ana Lleo; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Ana Teles; Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Ploen, Germany
- Anders Kildal; Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromso, Norway
- Andrea Biondi; Pediatric Departement and Centro Tettamanti- European Reference Network (ERN) PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM/Osped
- Andrea Caballero-Garralda; Biochemistry Department, Echevarne Laboratory, Sant Cugat del Valles, Barcelona, Spain
- Andrea Ganna; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Andrea Gori; Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy
- Andreas Glueck; Klinik fuer Innere Medizin I, Universitaetsklinikum Schleswig-Holstein, Campus Kiel, Germany
- Andreas Lind; Department of Microbiology, Oslo University Hospital, Oslo, Norway
- Anja Tanck; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Anke Hinney; Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- Anna Carreras Carreras Nolla; Genomes for Life-GCAT lab. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Anna Ludovica Fracanzani; University of Milan, Milan, Italy
- Anna Peschuck; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Annalisa Cavallero; Laboratory of Microbiology, San Gerardo Hospital, Monza, Italy
- Anne Ma Dyrhol-Riise; Department of Infectious diseases, Oslo University Hospital, Oslo, Norway
- Antonella Ruello; Humanitas Gavazzeni-Castelli, Bergamo, Italy
- Antonio Julia; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
- Antonio Muscatello; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Antonio Pesenti; University of Milan, Milan, Italy
- Antonio Voza; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
- Ariadna Rando-Segura; Microbiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
- Aurora Solier; Department of Respiratory Diseases, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of Alcala, Cen
- Axel Schmidt; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
- Beatriz Cortes; Genomes for Life-GCAT lab. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Beatriz Mateos; Department of Gastroenterology, Hospital Universitario Ramon y Cajal, University of Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid,
- Beatriz Nafria-Jimenez; Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, Clinical Biochemistry Department, San Sebastian, Spain
- Benedikt Schaefer; Medical University of Innsbruck, Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Innsbruck, Austria
- Bjoern Jensen; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Ger
- Carla Bellinghausen; Department of Respiratory Medicine and Allergology, University Hospital, Goethe University, Frankfurt am Main, Germany
- Carlo Maj; Institute of Genomic Statistics and Bioinformatics, University Hospital Bonn, Medical Faculty University of Bonn, Venusberg-Campus 1, Bonn, Germany
- Carlos Ferrando; Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
- Carmen de la Horra; University of Sevilla, Sevilla, Spain
- Carmen Quereda; Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of Alcala, Madr
- Carsten Skurk; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Charlotte Thibeault; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Chiara Scollo; Department of Transfusion Medicine and Haematology Laboratory, San Gerardo Hospital, Monza, Italy
- Christian Herr; Department of Internal Medicine V, Pneumology, Allergology and Intensive Care Medicine, University Hospital Saarland, Homburg/Saar, Germany
- Christoph D Spinner; Technical University of Munich, School of Medicine, University Hospital rechts der Isar, Department of Internal Medicine II, Munich, Germany
- Christoph Gassner; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Christoph Lange; Respiratory Medicine & International Health, University of Luebeck, Luebeck, Germany
- Cinzia Hu; Internal Medicine Department,Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Cinzia Paccapelo; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Clara Lehmann; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Claudio Angelini; Humanitas Clinical and Research Center, IRCCS, Milan, Italy
- Claudio Cappadona; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
- Clinton Azuure; Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Ploen, Germany
- Cristiana Bianco; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Cristina Cea; Department of Biochemistry, University Hospital Vall d'Hebron, Barcelona, Spain
- Cristina Sancho; Osakidetza Basque Health Service, Basurto University Hospital, Respiratory Service, Bilbao, Spain
- Dag Arne Lihaug Hoff; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
- Daniela Galimberti; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Daniele Prati; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- David Haschka; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
- David Jimenez; Department of Respiratory Diseases, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of Alcala, Cen
- David Pestana; Department of Anesthesiology and Critical Care, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of
- David Toapanta; Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Eduardo Muniz-Diaz; Immunohematology Department, Banc de Sang i Teixits, Autonomous University of Barcelona, Barcelona, Spain
- Elena Azzolini; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Elena Sandoval; Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Eleonora Binatti; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy
- Elio Scarpini; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Elisa T Helbig; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Elisabetta Casalone; Department of Medical Sciences, Universita degli Studi di Torino, Turin, Italy
- Eloisa Urrechaga; Osakidetza Basque Health Service, Galdakao Hospital, Respiratory Service, Galdakao, Spain
- Elvezia Maria Paraboschi; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Emanuele Pontali; Department of Infectious Diseases, E.O. Ospedali Galliera, Genova, Italy
- Enric Reverter; Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Enrique J Calderon; University of Sevilla, Sevilla, Spain
- Enrique Navas; Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of Alcala, Madr
- Erik Solligard; Geminicenter for Sepsis Research, Institute of Circulation and Medical Imaging (ISB), NTNU, Trondheim, Norway
- Ernesto Contro; Accident & Emergency and Emergency Medicine Unit, San Gerardo Hospital, Monza, Italy
- Eunate Arana-Arri; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain
- Fatima Aziz; Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Federico Garcia; Microbiology Unit. Hospital Universitario Clinico San Cecilio, Granada, Spain
- Felix Garcia Sanchez; Histocompatibilidad y Biologia Molecular, Centro de Transfusion de Madrid, Madrid, Spain
- Ferruccio Ceriotti; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Filippo Martinelli-Boneschi; Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
- Flora Peyvandi; University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy
- Florian Kurth; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Francesco Blasi; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Respiratory Unit, Milan, Italy
- Francesco Malvestiti; University of Milan, Milan, Italy
- Francisco J Medrano; Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain
- Francisco Mesonero; Department of Gastroenterology, Hospital Universitario Ramon y Cajal, University of Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid,
- Francisco Rodriguez-Frias; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
- Frank Hanses; Emergency Department, University Hospital Regensburg, Regensburg, Germany
- Fredrik Mueller; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Georg Hemmrich-Stanisak; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Giacomo Bellani; Department Emergency, Anesthesia and Intensive Care, San Gerardo Hospital, Monza, Italy
- Giacomo Grasselli; University of Milan, Milan, Italy
- Gianni Pezzoli; Fondazione Grigioni per il Morbo di Parkinson and Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy
- Giorgio Costantino; University of Milan, Milan, Italy
- Giovanni Albano; Humanitas Gavazzeni-Castelli, Bergamo, Italy
- Giulia Cardamone; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
- Giuseppe Bellelli; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
- Giuseppe Citerio; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
- Giuseppe Foti; Department Emergency, Anesthesia and Intensive Care, San Gerardo Hospital, Monza, Italy
- Giuseppe Lamorte; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Giuseppe Matullo; Department of Medical Sciences, Universita degli Studi di Torino, Turin, Italy
- Guido Baselli; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Hayato Kurihara; Humanitas Clinical and Research Center, IRCCS, Milan, Italy
- Holger Neb; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
- Ilaria My; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Ingo Kurth; Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany
- Isabel Hernandez; Research Center and Memory Clinic. Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain
- Isabell Pink; Department of Pneumology, Hannover Medical School, Hannover, Germany
- Itziar de Rojas; Research Center and Memory Clinic. Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain
- Ivan Galvan-Femenia; Genomes for Life-GCAT lab. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Jan Cato Holter; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Jan Egil Afset; Department of Medical Microbiology, Clinic of Laboratory Medicine, St. Olavs hospital, Trondheim, Norway
- Jan Heyckendorf; Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
- Jan Kaessens; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Jan Kristian Damas; Department of Infectious Diseases, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
- Jan Rybniker; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Janine Altmueller; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany
- Javier Ampuero; University of Sevilla, Sevilla, Spain
- Javier Martin; Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain
- Jeanette Erdmann; Institute for Cardiogenetics, University of Luebeck, Luebeck, Germany
- Jesus M Banales; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EH
- Joan Ramon Badia; Respiratory ICU, Institut Clinic Respiratory, Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Joaquin Dopazo; Bioinformatics Area, Fundacion Progreso y Salud, and Institute of Biomedicine of Sevilla (IBIS), Sevilla, Spain
- Jochen Schneider; Technical University of Munich, School of Medicine, University Hospital rechts der Isar, Department of Internal Medicine II, Munich, Germany
- Jonas Bergan; Department of Research, Ostfold Hospital Trust, Gralum, Norway
- Jordi Barretina; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Joern Walter; Department of Genetics & Epigenetics, Saarland University, Saarbruecken, Germany
- Jose Hernandez Quero; Ibs.Granada Instituto de Investigacion Biosanitaria, Granada, Spain
- Josune Goikoetxea; Infectious Diseases Service, Osakidetza, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain
- Juan Delgado; University of Sevilla, Sevilla, Spain
- Juan M Guerrero; University of Sevilla, Sevilla, Spain
- Julia Fazaal; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
- Julia Kraft; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Julia Schroeder; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
- Kari Risnes; Department of Research, St Olav Hospital, Trondheim University Hospital, Trondheim, Norway
- Karina Banasik; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denm
- Karl Erik Mueller; Medical Department, Drammen Hospital, Vestre Viken Hospital Trust, Norway
- Karoline I Gaede; Research Center Borstel, BioMaterialBank Nord, Germany
- Koldo Garcia-Etxebarria; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EH
- Kristian Tonby; Department of Infectious diseases, Oslo University Hospital, Oslo, Norway
- Lars Heggelund; Department of Clinical Science, University of Bergen, Bergen, Norway
- Laura Izquierdo-Sanchez; Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain
- Laura Rachele Bettini; Pediatric Departement and Centro Tettamanti- European Reference Network (ERN) PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM/Osped
- Lauro Sumoy; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Leif Erik Sander; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Lena J Lippert; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Leonardo Terranova; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Lindokuhle Nkambule; Analytic & Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
- Lisa Knopp; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Ger
- Lise Tuset Gustad; Clinic of Medicine and Rehabilitation, Levanger Hospital, Nord-Trondelag Hospital Trust, Levanger, Norway
- Lucia Garbarino; HLA Laboratory, E.O. Ospedali Galliera, Genova, Italy
- Luigi Santoro; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Luis Tellez; Department of Gastroenterology, Hospital Universitario Ramon y Cajal, University of Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid,
- Luisa Roade; Universitat Autonoma de Barcelona, Bellatera, Spain
- Mahnoosh Ostadreza; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Maider Intxausti; Osakidetza Basque Health Service, Basurto University Hospital, Respiratory Service, Bilbao, Spain
- Manolis Kogevinas; ISGlobal, Barcelona, Spain
- Mar Riveiro-Barciela; Universitat Autonoma de Barcelona, Bellatera, Spain
- Marco Schaefer; Stefan-Morsch-Stiftung, Birkenfeld, Germany
- Mari EK Niemi; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Maria A Gutierrez-Stampa; Osakidetza, OSI Donostialdea, Altza Primary Care, Biodonostia Health Research Institute, San Sebastian, Spain
- Maria Carrabba; Internal Medicine Department,Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Maria E Figuera Basso; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Maria Grazia Valsecchi; Center of Bioinformatics, Biostatistics and Bioimaging, School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
- Maria Hernandez-Tejero; Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Maria JGT Vehreschild; Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt & Goethe University Frankfurt, Frankfurt am Main, Germany
- Maria Manunta; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Marialbert Acosta-Herrera; Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain
- Mariella D'Angio; Pediatric Departement and Centro Tettamanti- European Reference Network (ERN) PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM/Osped
- Marina Baldini; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Marina Cazzaniga; Phase 1 Research Centre, ASST Monza, School of Medicine and Surgery, University of Milano-Bicocca, Italy
- Marit M Grimsrud; Research Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University
- Markus Cornberg; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
- Markus M Noethen; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
- Marta Marquie; Research Center and Memory Clinic. Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain
- Massimo Castoldi; Humanitas Gavazzeni-Castelli, Bergamo, Italy
- Mattia Cordioli; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Maurizio Cecconi; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Mauro D'Amato; Gastrointestinal Genetics Lab, CIC bioGUNE, BRTA, Derio, Spain
- Max Augustin; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
- Melissa Tomasi; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Merce Boada; Research Center and Memory Clinic. Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain
- Michael Dreher; Department of Pneumology and Intensive Care Medicine, University Hospital Aachen, Germany
- Michael J Seilmaier; Munich Clinic Schwabing, Academic Teaching Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany
- Michael Joannidis; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
- Michael Wittig; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Michela Mazzocco; HLA Laboratory, E.O. Ospedali Galliera, Genova, Italy
- Michele Ciccarelli; Humanitas Clinical and Research Center, IRCCS, Milan, Italy
- Miguel Rodriguez-Gandia; Department of Gastroenterology, Hospital Universitario Ramon y Cajal, University of Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid,
- Monica Bocciolone; Humanitas Clinical and Research Center, IRCCS, Milan, Italy
- Monica Miozzo; Internal Medicine Department,Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Natale Imaz-Ayo; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain
- Natalia Blay; Genomes for Life-GCAT lab. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Natalia Chueca; Microbiology Unit. Hospital Universitario Clinico San Cecilio, Granada, Spain
- Nicola Montano; University of Milan, Milan, Italy
- Nicole Braun; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Nicole Ludwig; Center of Human and Molecular Biology, Department of Human Genetics, University Hospital Saarland, Homburg/Saar, Germany
- Nikolaus Marx; Department of Internal Medicine I, RWTH Aachen University Hospital, Aachen, Germany
- Nilda Martinez; Department of Anesthesiology, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid, Spain
- Oliver A Cornely; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Oliver Witzke; Department of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany
- Orazio Palmieri; Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
- Paola Faverio; Pulmonary Unit, San Gerardo Hospital, Monza, Italy
- Paoletta Preatoni; Humanitas Clinical and Research Center, IRCCS, Milan, Italy
- Paolo Bonfanti; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
- Paolo Omodei; Humanitas Clinical and Research Center, IRCCS, Milan, Italy
- Paolo Tentorio; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Pedro Castro; Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Pedro M Rodrigues; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EH
- Pedro Pablo Espana; Osakidetza Basque Health Service, Galdakao Hospital, Respiratory Service, Galdakao, Spain
- Per Hoffmann; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
- Philip Rosenstiel; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Philipp Schommers; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Phillip Suwalski; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Raul de Pablo; Department of Intensive Care, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of Alcala, Madrid, S
- Ricard Ferrer; Intensive Care Department, Vall d'Hebron University Hospital, SODIR-VHIR research group, Barcelona, Spain
- Robert Bals; Department of Internal Medicine V, Pneumology, Allergology and Intensive Care Medicine, University Hospital Saarland, Homburg/Saar, Germany
- Roberta Gualtierotti; University of Milan, Milan, Italy
- Rocio Gallego-Duran; Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain
- Rosa Nieto; Department of Respiratory Diseases, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), University of Alcala, Cen
- Rossana Carpani; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Ruben Morilla; Consejo Superior de Investigaciones cientificas, Sevilla, Spain
- Salvatore Badalamenti; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Sammra Haider; Department of Medicine, More & Romsdal Hospital Trust, Molde, Norway
- Sandra Ciesek; Institute of Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
- Sandra May; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Sara Bombace; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
- Sara Marsal; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
- Sara Pigazzini; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Sebastian Klein; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
- Serena Pelusi; University of Milan, Milan, Italy
- Sibylle Wilfling; Zentrum fuer Humangenetik Regensburg, Regensburg, Germany
- Silvano Bosari; University of Milan, Milan, Italy
- Sonja Volland; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
- Soren Brunak; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denm
- Soumya Raychaudhuri; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Stefan Schreiber; Klinik fuer Innere Medizin I, Universitaetsklinikum Schleswig-Holstein, Campus Kiel, Germany
- Stefanie Heilmann-Heimbach; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
- Stefano Aliberti; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
- Stephan Ripke; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Susanne Dudman; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Tanja Wesse; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Tenghao Zheng; School of Biological Sciences, Monash University, Clayton, VIC, Australia
- Thomas Bahmer; Klinik fuer Innere Medizin I, Universitaetsklinikum Schleswig-Holstein, Campus Kiel, Germany
- Thomas Eggermann; Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany
- Thomas Illig; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
- Thorsten Brenner; Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany
- Tomas Pumarola; Department of Microbiology, University Hospital Vall d'Hebron, Barcelona, Spain
- Torsten Feldt; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Ger
- Trine Folseraas; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital
- Trinidad Gonzalez Cejudo; Biochemistry Unit. Hospital Universitario Clinico San Cecilio, Granada, Spain
- Ulf Landmesser; Charite Universitaetsmedizin Berlin, Berlin Institute of Health, Berlin Germany
- Ulrike Protzer; Institute of Virology, Technical University Munich/Helmholtz Zentrum Muenchen, Munich, Germany
- Ute Hehr; Zentrum fuer Humangenetik Regensburg, Regensburg, Germany
- Valeria Rimoldi; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
- Valter Monzani; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Vegard Skogen; Department of Infectious Diseases, University Hospital of North Norway, Tromso, Norway
- Verena Keitel; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich Heine University, Duesseldorf, Ger
- Verena Kopfnagel; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
- Vicente Friaza; Consejo Superior de Investigaciones cientificas, Sevilla, Spain
- Victor Andrade; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University
- Victor Moreno; Catalan Institute of Oncology (ICO), Barcelona, Spain
- Wolfgang Albrecht; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Wolfgang Peter; Stefan-Morsch-Stiftung, Birkenfeld, Germany
- Wolfgang Poller; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Xavier Farre; Genomes for Life-GCAT lab. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Xiaoli Yi; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Xiaomin Wang; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Yascha Khodamoradi; Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt & Goethe University Frankfurt, Frankfurt am Main, Germany
- Zehra Karadeniz; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Anna Latiano; Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
- Siegfried Goerg; Institute of Transfusionsmedicine, University Hospital Schleswig-Holstein (UKSH), Germany
- Petra Bacher; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Philipp Koehler; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Florian Tran; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
- Heinz Zoller; Medical University of Innsbruck, Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Innsbruck, Austria
- Eva C Schulte; Institute of Virology, Technical University Munich/Helmholtz Zentrum Muenchen, Munich, Germany
- Bettina Heidecker; Charite Universitaetsmedizin Berlin, Berlin, Germany
- Kerstin U Ludwig; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
- Javier Fernandez; Hospital Clinic, University of Barcelona, and IDIBAPS, Barcelona, Spain
- Manuel Romero-Gomez; Centro de Investigacion Biomedica en Red en Enfermedades Hepaticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
- Agustin Albillos; Department of Gastroenterology, Hospital Universitario Ramon y Cajal, University of Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid,
- Pietro Invernizzi; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy
- Maria Buti; Universitat Autonoma de Barcelona, Bellatera, Spain
- Stefano Duga; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
- Luis Bujanda; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EH
- Johannes R Hov; Section for Gastroenterology, Department of Transplantation Medicine, Division for Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Riksho
- Tobias L Lenz; Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Ploen, Germany
- Rosanna Asselta; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Rafael de Cid; Genomes for Life-GCAT lab. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
- Luca Valenti; University of Milan, Milan, Italy
- Tom Hemming Karlsen; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital
- Mario Caceres; Institut de Biotecnologia i de Biomedicina, Universitat Autonoma de Barcelona, Bellaterra (Barcelona), Spain
- Andre Franke; University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Germany
- - COVICAT study group;
- - Covid-19 Aachen Study (COVAS);
- - Pa COVID-19 Study Group;
- - The Humanitas COVID-19 Task Force;
- - The Humanitas Gavazzeni COVID-19 Task Force;
- - Norwegian SARS-CoV-2 Study group;
Preprint
in English
| medRxiv
| ID: ppmedrxiv-21260624
ABSTRACT
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a highly pleiotropic [~]0.9-Mb inversion polymorphism and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
cc_by_nc_nd
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Type of study:
Cohort_studies
/
Observational study
/
Prognostic study
/
Review
Language:
English
Year:
2021
Document type:
Preprint
