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Development of a federated learning approach to predict acute kidney injury in adult hospitalized patients with COVID-19 in New York City
Suraj K Jaladanki; Akhil Vaid; Ashwin S Sawant; Jie Xu; Kush Shah; Sergio Dellepiane; Ishan Paranjpe; Lili Chan; Patricia Kovatch; Alexander Charney; Fei Wang; Benjamin S Glicksberg; Karandeep Singh; Girish N Nadkarni.
Affiliation
  • Suraj K Jaladanki; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Akhil Vaid; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Ashwin S Sawant; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Jie Xu; Weill Cornell Medicine
  • Kush Shah; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Sergio Dellepiane; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Ishan Paranjpe; Ican School of Medicine at Mount Sinai (ISMMS)
  • Lili Chan; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Patricia Kovatch; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Alexander Charney; Icahn School of Medicine at Mount Sinai
  • Fei Wang; Weill Cornell Medical College
  • Benjamin S Glicksberg; Icahn School of Medicine at Mount Sinai (ISMMS)
  • Karandeep Singh; University of Michigan Medical School
  • Girish N Nadkarni; Icahn School of Medicine at Mount Sinai (ISMMS)
Preprint in En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21261105
ABSTRACT
Federated learning is a technique for training predictive models without sharing patient-level data, thus maintaining data security while allowing inter-institutional collaboration. We used federated learning to predict acute kidney injury within three and seven days of admission, using demographics, comorbidities, vital signs, and laboratory values, in 4029 adults hospitalized with COVID-19 at five sociodemographically diverse New York City hospitals, between March-October 2020. Prediction performance of federated models was generally higher than single-hospital models and was comparable to pooled-data models. In the first use-case in kidney disease, federated learning improved prediction of a common complication of COVID-19, while preserving data privacy.
License
cc_by_nc_nd
Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Type of study: Prognostic_studies Language: En Year: 2021 Document type: Preprint
Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Type of study: Prognostic_studies Language: En Year: 2021 Document type: Preprint