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Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK.
Cori Campbell; Tingyan Wang; David A. Smith; Oliver Freeman; Theresa Noble; Kinga A. Varnai; Steve Harris; Hizni Salih; Gail Roadknight; Stephanie Little; Ben Glampson; Luca Mercuri; Dimitri Papadimitriou; Christopher R Jones; Vince Taylor; Afzal Chaudhry; Hang Phan; Florina Borca; Josune Olza; Frazer Warricker; Luis Romao; David Ramlakhan; Louise English; Paul Klenerman; Monique I. Andersson; Jane Collier; Eleni Nastouli; Salim I. Khakoo; William Gelson; Graham Cooke; Kerrie Woods; Jim Davies; Eleanor Barnes; Philippa C. Matthews.
Affiliation
  • Cori Campbell; University of Oxford
  • Tingyan Wang; University of Oxford
  • David A. Smith; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • Oliver Freeman; NIHR Oxford Biomedical Research Centre, Oxford, UK; Nuffield Department of Population Health, University of Oxford, Oxford, UK
  • Theresa Noble; NIHR Oxford Biomedical Research Centre, Oxford, UK; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • Kinga A. Varnai; NIHR Oxford Biomedical Research Centre, Oxford, UK; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • Steve Harris; NIHR Oxford Biomedical Research Centre, Oxford, UK; Department of Computer Science, University of Oxford, Oxford, UK
  • Hizni Salih; NIHR Oxford Biomedical Research Centre, Oxford, UK
  • Gail Roadknight; NIHR Oxford Biomedical Research Centre, Oxford, UK
  • Stephanie Little; NIHR Oxford Biomedical Research Centre, Oxford, UK
  • Ben Glampson; NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK; NIHR Imperial Biomedical Research Centre, London, UK
  • Luca Mercuri; NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK; NIHR Imperial Biomedical Research Centre, London, UK
  • Dimitri Papadimitriou; NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK; NIHR Imperial Biomedical Research Centre, London, UK
  • Christopher R Jones; Department of Infectious Disease, Imperial College London, London, UK
  • Vince Taylor; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • Afzal Chaudhry; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • Hang Phan; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
  • Florina Borca; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
  • Josune Olza; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
  • Frazer Warricker; University Hospital Southampton NHS Foundation Trust, Southampton, UK
  • Luis Romao; University College London Hospitals NHS Foundation Trust, London, UK
  • David Ramlakhan; University College London Hospitals NHS Foundation Trust, London, UK
  • Louise English; University College London Hospitals NHS Foundation Trust, London, UK
  • Paul Klenerman; Nuffield Department of Medicine, University of Oxford, UK; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust,
  • Monique I. Andersson; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Nuffield Department of Clinical Laboratory Sci
  • Jane Collier; Department of Hepatology, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK
  • Eleni Nastouli; Department of Clinical Virology, UCLH, London, UK
  • Salim I. Khakoo; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
  • William Gelson; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • Graham Cooke; Imperial College
  • Kerrie Woods; NIHR Oxford Biomedical Research Centre, Oxford, UK; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • Jim Davies; NIHR Oxford Biomedical Research Centre, Oxford, UK; Department of Computer Science, University of Oxford, Oxford, UK
  • Eleanor Barnes; Nuffield Department of Medicine, University of Oxford, UK; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • Philippa C. Matthews; Nuffield Department of Medicine, University of Oxford, UK; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK;
Preprint in English | medRxiv | ID: ppmedrxiv-21265651
ABSTRACT
Background and aimsTo determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine surveillance (ALT and HBV viral load). MethodsWe used anonymised electronic health record data from the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) pipeline representing five UK NHS Trusts. ResultsWe report significant reductions in surveillance of both biomarkers during the pandemic compared to pre-COVID years, both in terms of the proportion of patients who had [≥]1 measurement annually, and the mean number of measurements per patient. ConclusionsFurther investigation is required to determine whether these disruptions will be associated with increased rates of adverse chronic HBV outcomes.
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort_studies / Experimental_studies / Prognostic study Language: English Year: 2021 Document type: Preprint
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort_studies / Experimental_studies / Prognostic study Language: English Year: 2021 Document type: Preprint