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Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms
Caroline G. Atyeo; Lydia L. Shook; Sarah Brigida; Rose M. De Guzman; Stepan Demidkin; Cordelia Muir; Babatunde Akinwunmi; Arantxa Medina Baez; Erin McSweeney; Madeleine Burns; Ruhi Nayak; Maya K. Kumar; Chinmay D. Patel; Allison Fialkowski; Dana Cvrk; Ilona T. Goldfarb; Lael M. Yonker; Alessio Fasano; Michal A. Elovitz; Kathryn J. Gray; Galit Alter; Andrea G. Edlow.
Affiliation
  • Caroline G. Atyeo; Ragon Institute of MGH, MIT, and Harvard
  • Lydia L. Shook; Massachusetts General Hospital
  • Sarah Brigida; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Rose M. De Guzman; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Stepan Demidkin; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Cordelia Muir; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Babatunde Akinwunmi; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School
  • Arantxa Medina Baez; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Erin McSweeney; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Madeleine Burns; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital
  • Ruhi Nayak; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Maya K. Kumar; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School
  • Chinmay D. Patel; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School
  • Allison Fialkowski; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital
  • Dana Cvrk; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Ilona T. Goldfarb; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
  • Lael M. Yonker; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital
  • Alessio Fasano; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital
  • Michal A. Elovitz; Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania
  • Kathryn J. Gray; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School
  • Galit Alter; Ragon Institute of MGH, MIT, and Harvard
  • Andrea G. Edlow; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
Preprint in English | medRxiv | ID: ppmedrxiv-21266273
ABSTRACT
The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing of vaccination in pregnancy impact maternal and neonatal immunity. Here, we characterized the antibody profile after Ad26.COV2.S, mRNA-1273 or BNT162b2 vaccination in 158 pregnant individuals, and evaluated transplacental antibody transfer by profiling maternal and umbilical cord blood in 175 maternal-neonatal dyads. These analyses revealed lower vaccine-induced functions and Fc-receptor binding after Ad26.COV2.S compared to mRNA vaccination, and subtle advantages in titer and function with mRNA-1273 versus BN162b2. mRNA vaccinees had higher titers and functions against SARS-CoV-2 variants of concern. First and third trimester vaccination resulted in enhanced maternal immune responses relative to second trimester. Higher cordmaternal transfer ratios following first and second trimester vaccination reflect placental compensation for waning maternal titers. These results support vaccination early in pregnancy to maximize maternal protection throughout gestation, without compromising neonatal antibody protection.
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Experimental_studies Language: English Year: 2021 Document type: Preprint
Fulltext
Add to My VHL
Print
XML
Search on Google
Full text: Available Collection: Preprints Database: medRxiv Type of study: Experimental_studies Language: English Year: 2021 Document type: Preprint