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Genetic overlap between idiopathic pulmonary fibrosis and COVID-19
Preprint
in English
| medRxiv
| ID: ppmedrxiv-21267459
ABSTRACT
Genome-wide association studies (GWAS) of coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) have identified genetic loci associated with both traits, suggesting possible shared biological mechanisms. Using updated GWAS of COVID-19 and IPF, we evaluated the genetic overlap between these two diseases and identified four genetic loci (including one novel) with likely shared causal variants between severe COVID-19 and IPF. Although there was a positive genetic correlation between COVID-19 and IPF, two of these four shared genetic loci had an opposite direction of effect. IPF-associated genetic variants related to telomere dysfunction and spindle assembly showed no association with COVID-19 phenotypes. Together, these results suggest there are both shared and distinct biological processes driving IPF and severe COVID-19 phenotypes.
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Full text:
Available
Collection:
Preprints
Database:
medRxiv
Type of study:
Experimental_studies
Language:
English
Year:
2021
Document type:
Preprint
