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Third BNT162b2 vaccination neutralization of SARS-CoV-2 Omicron infection
Preprint
in English
| medRxiv
| ID: ppmedrxiv-21267670
ABSTRACT
Using isolates of SARS-CoV-2 WT, Beta, Delta and most importantly Omicron we studied the capability of the BNT162b2 vaccine given in two or three doses to neutralize major SARS-CoV-2 variants of concern (VOC). We demonstrate low neutralization efficiency against delta and wild-type for vaccines with more than 5 months following the second BNT162b2 dose, with no neutralization efficiency against Omicron. We demonstrate the importance of a third dose, by showing a 100-fold increase in neutralization efficiency of Omicron following a third dose, with a 4-fold reduced neutralization compared to that against the Delta VOC. The durability of the effect of the third dose is yet to be determined.
cc_by_nc
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Language:
English
Year:
2021
Document type:
Preprint
