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T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all prior infected and vaccinated individuals
Vivek Naranbhai; Anusha Nathan; Clarety Kaseke; Cristhian Berrios; Ashok Khatri; Shawn Choi; Matthew Aaron Getz; Rhoda Kesewaa Kesewaa Tano-Menka; Onosereme Ofoman; Alton Charles Gayton; Fernando Senjobe; Kerri St. Denis; Evan Christopher Lam; Wilfredo F Garcia-Beltran; Alejandro B Balazs; Bruce D Walker; A. John Iafrate; Gaurav Das Gaiha.
Affiliation
  • Vivek Naranbhai; Massachusetts General Hospital/ Dana Farber Cancer Institute
  • Anusha Nathan; Ragon Institute of MGH MIT and Harvard
  • Clarety Kaseke; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Cristhian Berrios; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
  • Ashok Khatri; Massachusetts General Hospital Endocrine Division and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
  • Shawn Choi; Massachusetts General Hospital Endocrine Division and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
  • Matthew Aaron Getz; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Rhoda Kesewaa Kesewaa Tano-Menka; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Onosereme Ofoman; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
  • Alton Charles Gayton; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Fernando Senjobe; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Kerri St. Denis; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Evan Christopher Lam; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Wilfredo F Garcia-Beltran; Ragon Institute of MGH, MIT, and Harvard
  • Alejandro B Balazs; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Bruce D Walker; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • A. John Iafrate; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
  • Gaurav Das Gaiha; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
Preprint in English | medRxiv | ID: ppmedrxiv-21268586
ABSTRACT
The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from infection and vaccine-induced antibody responses, although the extent to which these substitutions in spike and non-spike proteins affect T cell recognition is unknown. Here we show that T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins. However, we also identify a subset of individuals ([~]21%) with a >50% reduction in T cell reactivity to the Omicron spike. Evaluation of functional CD4+ and CD8+ memory T cell responses confirmed these findings and reveal that reduced recognition to Omicron spike is primarily observed within the CD8+ T cell compartment. Booster vaccination substantially enhanced T cell responses to Omicron spike. In contrast to neutralizing immunity, these findings suggest preservation of T cell responses to the Omicron variant, although with reduced reactivity in some individuals.
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Experimental_studies Language: English Year: 2022 Document type: Preprint
Fulltext
Add to My VHL
Print
XML
Search on Google
Full text: Available Collection: Preprints Database: medRxiv Type of study: Experimental_studies Language: English Year: 2022 Document type: Preprint