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Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity
Lauren B. Rodda; Peter A. Morawski; Kurt B. Pruner; Mitchell L. Fahning; Christian A. Howard; Nicholas Franko; Jennifer Logue; Julie Eggenberger; Caleb Stokes; Inah Golez; Malika Hale; Michael Gale Jr.; Helen Y Chu; Daniel J. Campbell; Marion Pepper.
Affiliation
  • Lauren B. Rodda; Department of Immunology, University of Washington School of Medicine, Seattle, WA USA, 98109.
  • Peter A. Morawski; Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA USA, 98101.
  • Kurt B. Pruner; Department of Immunology, University of Washington School of Medicine, Seattle, WA USA, 98109.
  • Mitchell L. Fahning; Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA USA, 98101.
  • Christian A. Howard; Department of Immunology, University of Washington School of Medicine, Seattle, WA USA, 98109.
  • Nicholas Franko; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, USA, 98109.
  • Jennifer Logue; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, USA, 98109.
  • Julie Eggenberger; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA, 98109.
  • Caleb Stokes; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA, 98109.
  • Inah Golez; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA, 98109.
  • Malika Hale; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA
  • Michael Gale Jr.; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA, 98109.
  • Helen Y Chu; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, USA, 98109.
  • Daniel J. Campbell; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, USA, 98109.
  • Marion Pepper; Department of Immunology, University of Washington School of Medicine, Seattle, WA USA, 98109.
Preprint in English | medRxiv | ID: ppmedrxiv-22269192
ABSTRACT
Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen exposures. Both SARS-CoV-2 infection and vaccination induce multifaceted, functional immune memory, but together they engender improved protection from disease, termed "hybrid immunity". We therefore investigated how vaccine-induced memory is shaped by previous infection. We found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-{gamma} and IL-10-expressing memory SARS-CoV-2 spike-specific CD4+ T cells than previously naive individuals. While additional vaccination could increase humoral memory, it did not recapitulate the distinct CD4+ T cell cytokine profile in previously naive individuals. Thus, imprinted features of SARS-CoV-2-specific memory lymphocytes define hybrid immunity.
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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2022 Document type: Preprint
Fulltext
Add to My VHL
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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2022 Document type: Preprint