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Correlation between post-vaccination titres of combined IgG, IgA, and IgM anti-Spike antibodies and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study (COVIDENCE UK)
Giulia Vivaldi; David A Jolliffe; Sian Faustini; Hayley Holt; Natalia Perdek; Mohammad Talaei; Florence Tydeman; Emma S Chambers; Weigang Cai; Wenhao Li; Joseph M Gibbons; Corinna Pade; Áine McKnight; Seif O Shaheen; Alex G Richter; Adrian R Martineau.
Affiliation
  • Giulia Vivaldi; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • David A Jolliffe; Blizard Institute and the Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London
  • Sian Faustini; Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
  • Hayley Holt; Blizard Institute and the Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London
  • Natalia Perdek; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Mohammad Talaei; Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Florence Tydeman; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Emma S Chambers; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Weigang Cai; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Wenhao Li; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Joseph M Gibbons; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Corinna Pade; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Áine McKnight; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Seif O Shaheen; Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Alex G Richter; Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
  • Adrian R Martineau; Blizard Institute and the Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London
Preprint in English | medRxiv | ID: ppmedrxiv-22270667
ABSTRACT
In this population-based cohort of 7530 adults, combined IgG/A/M anti-Spike titres measured after SARS-CoV-2 vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure including household overcrowding, public transport use, and visits to indoor public places.
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort_studies / Observational study / Prognostic study Language: English Year: 2022 Document type: Preprint
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort_studies / Observational study / Prognostic study Language: English Year: 2022 Document type: Preprint