SARS-CoV-2 neutralization after mRNA vaccination and variant breakthrough infection

Christian Gaebler; Justin DaSilva; Eva Bednarski; Frauke Muecksch; Fabian Schmidt; Yiska Weisblum; Katrina Millard; Martina Turroja; Alice Cho; Zijun Wang; Marina Caskey; Michel C. Nussenzweig; Paul Bieniasz; Theodora Hatziioannou

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SARS-CoV-2 neutralization after mRNA vaccination and variant breakthrough infection

Christian Gaebler; Justin DaSilva; Eva Bednarski; Frauke Muecksch; Fabian Schmidt; Yiska Weisblum; Katrina Millard; Martina Turroja; Alice Cho; Zijun Wang; Marina Caskey; Michel C. Nussenzweig; Paul Bieniasz; Theodora Hatziioannou.

Affiliation

Christian Gaebler; The Rockefeller University
Justin DaSilva; The Rockefeller University, New York
Eva Bednarski; The Rockefeller University, New York
Frauke Muecksch; The Rockefeller University, New York, NY
Fabian Schmidt; The Rockefeller University, New York
Yiska Weisblum; The Rockefeller University, New York
Katrina Millard; The Rockefeller University, New York
Martina Turroja; The Rockefeller University, New York
Alice Cho; The Rockefeller University, New York
Zijun Wang; The Rockefeller University, New York
Marina Caskey; The Rockefeller University
Michel C. Nussenzweig; The Rockefeller University, New York
Paul Bieniasz; Rockefeller University
Theodora Hatziioannou; The Rockefeller University, New York

Preprint in English | medRxiv | ID: ppmedrxiv-22270692

ABSTRACT

ABSTRACT

Vaccination and infection by viral variants are shaping population immunity to SARS-CoV-21 and breakthrough infections of vaccinated or previously infected individuals have become common as variants evade preexisting immunity. Omicron (B.1.1.529) is highly resistant to plasma neutralizing antibodies elicited by infection with prior variants and the 2-dose mRNA vaccination regimens. However, vaccination after infection or a third mRNA vaccine dose elicit high levels of neutralizing antibodies that can also neutralize omicron to a degree2-4. We compared neutralizing antibody titers in 54 individuals that had received 2 or 3 doses of mRNA vaccines and had experienced breakthrough infection with SARS-CoV-2 variants.

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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2022 Document type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2022 Document type: Preprint