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Potency and Breadth of Neutralization after 3 doses of mRNA vaccines in COVID-19 Convalescent and Naive individuals
Joanna Luczkowiak; Gonzalo Rivas; Nuria Labiod; Fatima Lasala; Marta Rolo; Jaime Lora-Tamayo; Mikel Mancheno-Losa; David Rial-Crestelo; Maria D Folgueira; Rafael Delgado.
Affiliation
  • Joanna Luczkowiak; Instituto de Investigacion Hospital 12 de Octubre
  • Gonzalo Rivas; Department of Microbiology Hospital Universitario 12 de Octubre
  • Nuria Labiod; Instituto de Investigacion Hospital 12 de Octubre
  • Fatima Lasala; Instituto de Investigacion Hospital 12 de Octubre
  • Marta Rolo; Department of Microbiology Hospital Universitario 12 de Octubre
  • Jaime Lora-Tamayo; Department of Internal Medicine. Hospital Universitario 12 de Octubre
  • Mikel Mancheno-Losa; Department of Internal Medicine. Hospital Universitario 12 de Octubre
  • David Rial-Crestelo; Department of Internal Medicine. Hospital Universitario 12 de Octubre
  • Maria D Folgueira; Department of Microbiology. Hospital Universitario 12 de Octubre
  • Rafael Delgado; Department of Microbiology Hospital Universitario 12 de Octubre
Preprint in En | PREPRINT-MEDRXIV | ID: ppmedrxiv-22272557
ABSTRACT
Third doses of mRNA COVID-19 vaccines induced a significant increase in neutralizing potency and breadth in naive individuals comparable with convalescents who restored levels after the first two doses. These results suggest a limit to elicit neutralization in the number of stimuli by infection or vaccination with ancestral SARS-CoV-2 sequences
License
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Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Language: En Year: 2022 Document type: Preprint
Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Language: En Year: 2022 Document type: Preprint