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COVID-19 vaccine effectiveness during a prison outbreak when the Omicron was the dominant circulating variant, Zambia, December 2021
John Simwanza; Jonas Z. Hines; Danny Sinyange; Nyambe Sinyange; Chilufya Mulenga; Sarah Hanyinza; Patrick Sakubita; Nelia Langa; Haggai Nowa; Priscilla Gardner; Ngonda Saasa; Gabriel Chipeta; James Simpungwe; Warren Malambo; Busiku Hamainza; Nathan Kapata; Muzala Kapina; Kunda Musonda; Mazyanga Liwewe; Consity Mwale; Sombo Fwoloshi; Lloyd B. Mulenga; Simon Agolory; Victor Mukonka; Roma Chilengi.
Affiliation
  • John Simwanza; Zambia Field Epidemiology Training Program
  • Jonas Z. Hines; U.S. Centers for Disease Control and Prevention
  • Danny Sinyange; Zambia Field Epidemiology Training Program
  • Nyambe Sinyange; Zambia National Public Health Institute
  • Chilufya Mulenga; Zambia Field Epidemiology Training Program
  • Sarah Hanyinza; Zambia National Public Health Institute
  • Patrick Sakubita; Zambia National Public Health Institute
  • Nelia Langa; Zambia National Public Health Institute
  • Haggai Nowa; Zambia Prison Services
  • Priscilla Gardner; Lusaka District Health Office
  • Ngonda Saasa; University of Zambia Veterinary Medicine Laboratory School
  • Gabriel Chipeta; Lusaka District Health Office
  • James Simpungwe; U.S. Centers for Disease Control and Prevention
  • Warren Malambo; U.S. Centers for Disease Control and Prevention
  • Busiku Hamainza; National Malaria Elimination Centre
  • Nathan Kapata; Zambia National Public Health Institute
  • Muzala Kapina; Zambia National Public Health Institute
  • Kunda Musonda; Zambia National Public Health Institute
  • Mazyanga Liwewe; Zambia National Public Health Institute
  • Consity Mwale; Lusaka Province Health Office
  • Sombo Fwoloshi; Zambia Ministry of Health
  • Lloyd B. Mulenga; Zambia Ministry of Health
  • Simon Agolory; U.S. Centers for Disease Control and Prevention
  • Victor Mukonka; Zambia National Public Health Institute
  • Roma Chilengi; Zambia National Public Health Institute
Preprint in English | medRxiv | ID: ppmedrxiv-22274701
ABSTRACT
During a COVID-19 outbreak in a prison in Zambia from 14th to 19th December 2021, a case control study was done to measure vaccine effectiveness (VE) against infection and symptomatic infection, when the Omicron variant was the dominant circulating variant. Among 382 participants, 74.1% were fully vaccinated and the median time since full vaccination was 54 days. There were no hospitalizations or deaths. COVID-19 VE against any SARS-CoV-2 infection was 64.8% and VE against symptomatic SARS-CoV-2 infection was 72.9%. COVID-19 vaccination helped protect incarcerated persons against SARS-CoV-2 infection during an outbreak while Omicron was the dominant variant in Zambia.
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Full text: Available Collection: Preprints Database: medRxiv Type of study: Experimental_studies / Observational study Language: English Year: 2022 Document type: Preprint
Full text: Available Collection: Preprints Database: medRxiv Type of study: Experimental_studies / Observational study Language: English Year: 2022 Document type: Preprint
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