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Lineage BA.2 dominated the Omicron SARS-CoV-2 epidemic wave in the Philippines
Yao-Tsun Li; Francisco Gerardo M. Polotan; Gerald Ivan S. Sotelo; Anne Pauline A. Alpino; Ardiane Ysabelle M. Dolor; Ma. Angelica A. Tujan; Ma. Ricci R. Gomez; Othoniel Jan T. Onza; Angela Kae T. Chang; Criselda T. Bautista; June C. Carandang; Dodge R. Lim; Lei Lanna M. Dancel; Mayan U. Lumandas; Timothy John R. Dizon; Katie Hampson; Simon Daldry; Joseph Hughes; Kirstyn Brunker.
Affiliation
  • Yao-Tsun Li; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow
  • Francisco Gerardo M. Polotan; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Gerald Ivan S. Sotelo; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Anne Pauline A. Alpino; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Ardiane Ysabelle M. Dolor; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Ma. Angelica A. Tujan; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Ma. Ricci R. Gomez; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Othoniel Jan T. Onza; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Angela Kae T. Chang; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Criselda T. Bautista; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • June C. Carandang; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Dodge R. Lim; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Lei Lanna M. Dancel; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Mayan U. Lumandas; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Timothy John R. Dizon; Research Institute for Tropical Medicine, Muntinlupa City, Philippines
  • Katie Hampson; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow
  • Simon Daldry; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow
  • Joseph Hughes; MRC-University of Glasgow Centre for Virus Research
  • Kirstyn Brunker; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow
Preprint in English | medRxiv | ID: ppmedrxiv-22275783
ABSTRACT
The Omicron SARS-CoV-2 variant led to a dramatic global epidemic wave following detection in South Africa in November, 2021. The Omicron lineage BA.1 was dominant and responsible for most domestic outbreaks during December 2021-January 2022, whilst other Omicron lineages including BA.2 accounted for the minority of global isolates. Here, we describe the Omicron wave in the Philippines by analysing genomic data. Our results identify the presence of both BA.1 and BA.2 lineages in the Philippines in December 2021, before cases surged in January 2022. We infer that only lineage BA.2 underwent sustained transmission in the country, with an estimated emergence around November 18th, 2021 [95% highest posterior density November 6-28th], whilst despite multiple introductions BA.1 transmission remained limited. These results suggest the Philippines was one of the earliest areas affected by BA.2, and reiterate the importance of whole-genome sequencing for monitoring outbreaks.
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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2022 Document type: Preprint
Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2022 Document type: Preprint
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