This article is a Preprint
Preprints are preliminary research reports that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Preprints posted online allow authors to receive rapid feedback and the entire scientific community can appraise the work for themselves and respond appropriately. Those comments are posted alongside the preprints for anyone to read them and serve as a post publication assessment.
SARS-CoV-2 seroprevalence among public school staff in Metro Vancouver after the first Omicron wave in British Columbia, Canada
Preprint
in English
| medRxiv
| ID: ppmedrxiv-22277230
ABSTRACT
ObjectiveTo determine the SARS-CoV-2 seroprevalence among school workers in the setting of full in-person schooling and the highly transmissible Omicron variants of concern. DesignCross-sectional study among school staff, comparing to period-, age-, sex- and postal code-weighted data from Canadian blood donors from the same community. SettingThree large school districts in the greater Vancouver metropolitan area, British Columbia, Canada, with serology sampling done between January 26, 2022 and April 8, 2022. ParticipantsSchool staff actively working in the Vancouver, Richmond and Delta School Districts. Main outcome measureSARS-CoV-2 seroprevalence based on nucleocapsid (N)-protein testing, adjusted for the sensitivity and specificity of the assay. ResultsA majority (65.8%) of the 1845 school staff enrolled reported close contact with a COVID-19 case outside the household. Of those, about half reported close contact with a COVID-19 case at school either in a student (51.5%) or co-worker (54.9%). In a representative sample of 1620 (87.8%) school staff, the adjusted seroprevalence was 26.5% [95%CrI 23.9 - 29.3%]. This compared to an age, sex and residency area-weighted seroprevalence of 32.4% [95%CrI 30.6 - 34.5%] among 7164 blood donors. ConclusionDespite frequent COVID-19 exposures, the prevalence of SARS-CoV-2 infections among the staff of three main school districts in the Vancouver metropolitan area was no greater than a reference group of blood donors, even after the emergence of the more transmissible Omicron variant. What is already known on this subject?O_LIEarlier studies indicate that COVID-19 infection rates are not increased among school staff at previous stages of the pandemic compared to the community, yet controversy remains whether this will remain true after the emergence of the highly transmissible Omicron variant. C_LI What this study adds?O_LIDespite frequent COVID-19 exposures, this study identified no detectable increase in SARS-CoV-2 seroprevalence among school staff working in three metro Vancouver public school districts after the first Omicron wave in British Columbia, compared to a reference group of blood donors from the same age, sex and community area. C_LI
cc_by_nc_nd
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Language:
English
Year:
2022
Document type:
Preprint