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Prevalence of and factors associated with polypharmacy and potential drug interactions in adults in Manaus city, Brazil: a cross-sectional population-based study, 2019 / Prevalencia y factores asociados a la polifarmacia y posibles interacciones farmacológicas en adultos en la ciudad de Manaus, Brasil: estudio transversal poblacional, 2019 / Prevalência e fatores associados à polifarmácia e potenciais interações medicamentosas em adultos na cidade de Manaus: estudo transversal de base populacional, 2019
Preprint
in Portuguese
| SciELO Preprints
| ID: pps-3755
Responsible library:
BR1.1
ABSTRACT
Objective:
To assess the prevalence and factors associated with polypharmacy and the presence of potential drug interactions among these individuals in Manaus, estado do Amazonas, Brazil, in 2019.Methods:
Cross-sectional population-based study conducted with adults aged ≥18 years. Among people on polypharmacy (≥5 medicines), the presence of drug interactions was investigated in the icromedex database. Prevalence ratios (PR) were calculated by Poisson regression with robust variance, following hierarchical analysis and considering the complex sample design.Results:
Out of the 2,321 participants were included, 2.8% (95%CI 2.1;3.6) were on polypharmacy, of which 74.0% presented drug interactions, with four or more interactions per person (40.4%) and high severity (59.5%) being the most frequent. Polypharmacy was higher among the elderly (PR=3.24 95%CI 1.25;8.42), poor health (PR=2.54 95%CI 1.14;5.67), previous hospitalization (PR=1.90 95%CI 1.09;3.32) and multimorbidity (PR=3.20 95%CI 1.53;6.67).Conclusion:
Polypharmacy was more frequent among the elderly and people with health problems, who potentially had more drug interactions.RESUMEN
Objetivo:
Analizar la prevalencia y factores asociados a polifarmacia y la presencia de posibles interacciones farmacológicas en Manaus, estado do Amazonas, Brasil, en 2019.Métodos:
Estudio poblacional transversal realizado con adultos con edad ≥18 años. Entre personas en polifarmacia (≥5 medicamentos), se investigó la presencia de interacciones farmacológicas en Micromedex. Razones de prevalencia (RP) se calcularon mediante regresión de Poisson con varianza robusta, siguiendo análisis jerárquico y considerando el diseño de muestra complejo.Resultados:
De los 2.321 participantes, 2,8% (IC95% 2,1;3,6) se encontraban en polifarmacia, de los cuales 74,0% presentaban interacciones, siendo más frecuentes cuatro o más interacciones por persona (40,4%) y de alta gravedad (59,5%). Polifarmacia fue mayor entre los ancianos (RP=3,24 IC95% 1,25;8,42), mala salud (RP=2,54 IC95% 1,14;5,67), hospitalización previa (RP=1,90 IC95% 1,09;3,32) y multimorbilidade (RP=3,20 IC95% 1,53;6,67).Conclusión:
Polifarmacia fue más frecuente entre los ancianos y personas con problemas de salud, que potencialmente tenían más interacciones farmacológicas.RESUMO
Objetivo:
Analisar a prevalência e fatores associados à polifarmácia e a presença de potenciais interações medicamentosas em Manaus, estado do Amazonas, Brasil, em 2019.Métodos:
Estudo transversal de base populacional, com adultos na idade ≥18 anos. Entre pessoas em polifarmácia (≥5 medicamentos), pesquisou-se a presença de interações medicamentosas na base Micromedex. Razões de prevalências (RP) foram calculadas por regressão de Poisson com variância robusta, seguindo análise hierárquica e considerando o delineamento amostral complexo.Resultados:
Dos 2.321 participantes, 2,8% (IC95% 2,1;3,6) estavam em polifarmácia e destes, 74,0% apresentaram interações, sendo mais frequentes quatro ou mais interações por pessoa (40,4%) e gravidade alta (59,5%). Polifarmácia foi maior entre idosos (RP=3,24 IC95% 1,25;8,42), saúde ruim (RP=2,54 IC95% 1,14;5,67), hospitalização prévia (RP=1,90 IC95% 1,09;3,32) e multimorbidade (RP=3,20 IC95% 1,53;6,67).Conclusão:
A polifarmácia foi mais frequente entre idosos e pessoas com problemas de saúde, que tiveram mais interações medicamentosas.
Polimedicação; Interações Medicamentosas; Farmacoepidemiologia; Uso de Medicamentos; Inquéritos Epidemiológicos; Prevalência; Polypharmacy; Drug Interactions; Pharmacoepidemiology; Drug Utilization; Health Surveys; Prevalence; Polifarmacia; Interacciones Farmacológicas; Farmacoepidemiología; Utilización de Medicamentos; Encuestas Epidemiológicas; Prevalencia
Full text:
Available
Collection:
Preprints
Database:
SciELO Preprints
Type of study:
Observational study
/
Prevalence study
/
Risk factors
/
Screening study
Country/Region as subject:
South America
/
Brazil
Language:
Portuguese
Year:
2022
Document type:
Preprint