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COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE / EFEITO DO ÓLEO DE COCO NAS COMPLICAÇÕES DA DOENÇA HEPÁTICA
Preprint
in Portuguese
| SciELO Preprints
| ID: pps-4142
Responsible library:
BR1.1
ABSTRACT
Background:
Prevention of the progression of cirrhosis with dietary supplementation has been in focus Coconut oil has been suggested.Objective:
To evaluate the effect of coconut oil supplementation in cirrhotic rats.Method:
Forty Wistars were divided control (CO), control + coconut oil (CO + OC), thioacetamide (TAA) and thioacetamide + coconut oil (TAA + OC). TAA was added to water for 13 weeks and coconut oil was administered by gavage. Blood, liver, muscle and nervous tissue samples were obtained for laboratory and histopathological analyses.Results:
AST, ALT, total cholesterol, HDL, LDL, triglycerides were not statistically significant. In histology, even without differences, there was a tendency towards significance regarding the proliferation of bile ducts, fibrotic septa and muscle fiber atrophy between the TAA and TAA + OC groups.Conclusion:
No significant protective effect of coconut oil on liver disease was found.RESUMO
Racional A prevenção da evolução da cirrose com suplementação dietética tem estado em foco óleo de coco tem sido sugerido. Objetivo:
Avaliar o efeito da suplementação de óleo de coco em ratos cirróticos.Método:
Quarenta Wistar foram divididos controle (CO); controle + óleo de coco (CO+OC); tioacetamida (TAA) e tioacetamida + óleo de coco (TAA + OC). O TAA foi adicionado à água por 13 semanas e o óleo de coco administrado por gavagem. Amostras de sangue, fígado, tecido muscular e nervoso foram obtidas para análises laboratorial e histopatológica.Resultados:
AST, ALT, colesterol total, HDL, LDL, triglicérides não foram estatisticamente significantes. Na histologia, mesmo sem diferenças, houve tendência na significância quanto a proliferação de ductos biliares, septos fibróticos e atrofia da fibra muscular entre os grupos TAA e TAA + OC.Conclusão:
Não foi encontrado efeito protetor significativo do óleo de coco na doença hepática.
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Collection:
Preprints
Database:
SciELO Preprints
Language:
Portuguese
Year:
2022
Document type:
Preprint