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WHAT ARE THE CLINICAL- ENDOSCOPIC DIFFERENTIALS OF CELIAC DISEASE IN DYSPEPTIC SYNDROME? / QUAIS SÃO OS DIFERENCIAIS CLÍNICO- ENDOSCÓPICOS DA DOENÇA CELÍACA NA SÍNDROME DISPÉPTICA?
Preprint
in Portuguese
| SciELO Preprints
| ID: pps-7426
Responsible library:
BR1.1
ABSTRACT
Introduction:
Celiac disease is an autoimmune disease related to gluten that affects the small intestine. Dyspepsia is a set of symptoms of the upper abdomen that includes epigastric burning, postprandial fullness and early satiety and has a prevalence of 10-45% of the population with different etiological possibilities, including celiac disease.Objectives:
To evaluate the prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome and to study the sample regarding epidemiology, symptoms, endoscopic, histological and serological findings.Method:
Observational research, based on a review of medical records of patients treated for uninvestigated dyspepsia. Patients over 18 years of age, with this dyspepsia and who had endoscopy, total immunoglobulin A and IgA antitransglutaminase were included. Those with diarrhea, constipation, malabsorption, refractory lactose intolerance or who presented extraintestinal signs or symptoms suggestive of celiac disease were excluded.Results:
The initial sample was 1802 records and the final 200 patients. Of these, 100 had endoscopy, histology and antibody measurement, and the remaining 100 had endoscopy and antibody measurement, but not histology. Considering the total sample, the average age was 45.13 years and the female sex was predominant. Symptoms associated with gluten were reported in 6%. The antitransglutaminase antibody was positive in 1.5%. Considering the sample of 100 patients, the diagnosis of celiac disease had a prevalence of 3%.Conclusion:
The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%.RESUMO
Introdução:
A doença celíaca é doença autoimune relacionada ao glúten que acomete o intestino delgado. A dispepsia é um conjunto de sintomas do abdome superior que inclui queimação epigástrica, plenitude pós-prandial e saciedade precoce e apresenta prevalência de 10-45% da população cursando com diversas possibilidades etiológicas, incluindo a doença celíaca.Objetivos:
Avaliar a prevalência de doença celíaca em pacientes com diagnóstico clínico de síndrome dispéptica e estudar a amostra quanto à epidemiologia, sintomas, achados endoscópicos, histológicos e sorológicos.Método:
Estudo observacional, baseado na revisão de prontuários de pacientes atendidos por dispepsia não investigada. Foram incluídos pacientes acima de 18 anos, com essa dispepsia e que possuíssem endoscopia, imunoglobulina A total e antitransglutaminase IgA. Foram excluídos os com quadro diarreico, constipação, má-absorção, intolerância à lactose refratária ou que apresentassem sinais ou sintomas extraintestinais sugestivos de doença celíaca.Resultados:
A amostra inicial foi de 1802 registros e a final de 200 pacientes. Destes, 100 apresentavam endoscopia, histologia e dosagem de anticorpos, e os 100 restantes, endoscopia e dosagem de anticorpos, mas não histologia. Considerando o total da amostra a idade média foi de 45,13 anos e o sexo feminino foi predominante. Os sintomas associados ao glúten foram relatados em 6%. O anticorpo antitransglutaminase foi positivo em 1,5%. Considerando a amostra de 100 pacientes, o diagnóstico de doença celíaca teve prevalência de 3%.Conclusão:
A prevalência de doença celíaca em pacientes com diagnóstico clínico de síndrome dispéptica foi de 3%.
Full text:
Available
Collection:
Preprints
Health context:
Neglected Diseases
Health problem:
Diarrhea
Database:
SciELO Preprints
Language:
Portuguese
Year:
2023
Document type:
Preprint