Adjuvant effects of classical music on simvastatin induced reduction of anxiety but not object recognition memory in rats
Psychol. Neurosci. (impr.)
; 6(3): 403-410, 2013. graf
Article
in English
| Index Psychology - journals
| ID: psi-61610
Responsible library:
BR1.1
ABSTRACT
Simvastatin is one of many hydroxymethylglutaryl-coenzyme-A reductase inhibitors that are prescribed to lower cholesterol. Some emerging evidence indicates that classical music can serve as an effective adjuvant in rats treated with simvastatin. Moreover, simvastatin and classical music have been shown to influence some cognitive functions. To further understand the mechanisms of action, we exposed rats to classical music for 1 month, and then treated them orally with simvastatin. The behavioral experiments suggested that exposure to subchronic simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in the elevated plus-maze and open-field test in rats exposed to Mozart music. The recognition object test results indicated that simvastatin altered non-spatial working memory only at the 1 mg/kg/day dose and improved both short- and long-term object recognition. No significant differences were found between Mozart music and silence in the object recognition test, suggesting that music did not significant affect learning and memory in adult rats. We hypothesize that the anxiolytic, but not object-recognition memory, effects of simvastatin and classical music occur through similar mechanisms, providing an important foundation for future preclinical and clinical research.(AU)
Full text:
Available
Collection:
National databases
/
Brazil
Health problem:
En
Database:
Index Psychology - journals
Main subject:
Anxiety
/
Simvastatin
/
Memory, Long-Term
/
Memory, Short-Term
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Music
Limits:
Animals
Language:
English
Journal:
Psychol. Neurosci. (impr.)
Year:
2013
Document type:
Article
Institution/Affiliation country:
Universidade Regional de Blumenau/Brazil